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Evaluation of nitrate tolerance in patients with coronary heart disease by vascular ultrasonography and treadmill exercise
- Source :
- International journal of cardiology. 69(2)
- Publication Year :
- 1999
-
Abstract
- The aim of this study was to evaluate nitrate tolerance in patients with coronary heart diseases by vascular ultrasonography and treadmill exercise. According to the dosage interval of isosorbide dinitrate, 66 patients with coronary heart disease were divided into group A and group B in a random, control and double-blind method. Isosorbide dinitrate was given every 6 hours in group A and every 12 hours in group B for one week. Before and after the therapeutic period, the diameters of brachial arteries were measured by vascular ultrasonography at baseline and 5 min after sublingual administration of 10 mg isosorbide dinitrate, and the treadmill exercise test was performed in all subjects. The results showed that diameters of brachial arteries were increased significantly after sublingual isosorbide dinitrate in both groups before the therapeutic period. After the therapeutic period, dilation of brachial arteries induced by sublingual isosorbide dinitrate was more marked in group B than in group A. Compared with those before the therapeutic period, sigmaST segment depression decreased and treadmill walking time increased significantly in group B but not in group A after the therapeutic period. These findings suggest that less frequent doses of isosorbide dinitrate may prevent development of nitrate tolerance, which is confirmed by vascular ultrasonography combined with treadmill exercise in patients with coronary heart disease.
- Subjects :
- Adult
Male
medicine.medical_specialty
Isosorbide
Brachial Artery
medicine.medical_treatment
Vasodilator Agents
Coronary Disease
Isosorbide Dinitrate
Sublingual administration
law.invention
Randomized controlled trial
Double-Blind Method
law
Drug tolerance
medicine.artery
Internal medicine
medicine
Humans
Brachial artery
Aged
Ultrasonography
Chemotherapy
medicine.diagnostic_test
business.industry
Drug Tolerance
Middle Aged
Surgery
Cardiology
Exercise Test
Female
Isosorbide dinitrate
Cardiology and Cardiovascular Medicine
business
Electrocardiography
medicine.drug
Subjects
Details
- ISSN :
- 01675273
- Volume :
- 69
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International journal of cardiology
- Accession number :
- edsair.doi.dedup.....754d87efcad68df4058fa98ff16d31c3