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Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
- Source :
- Alzheimer's & dementia, vol. 15, no. 6, pp. 817-827, Kim, M, Snowden, S, Suvitaival, T, Ali, A, Merkler, D J, Ahmad, T, Westwood, S, Baird, A, Proitsi, P, Nevado-Holgado, A, Hye, A, Bos, I, Vos, S, Vandenberghe, R, Teunissen, C, ten Kate, M, Scheltens, P, Gabel, S, Meersmans, K, Blin, O, Richardson, J, de Roeck, E, Sleegers, K, Bordet, R G, Rami, L, Kettunen, P, Tsolaki, M, Verhey, F, Sala, I, Lléo, A, Peyratout, G, Tainta, M, Johannsen, P, Freund-Levi, Y, Frölich, L, Dobricic, V, Engelborghs, S, Frisoni, G B, Molinuevo, J L, Wallin, A, Popp, J, Martinez-Lage, P, Bertram, L, Barkhof, F, Ashton, N, Blennow, K, Zetterberg, H, Streffer, J, Visser, P J, Lovestone, S & Legido-Quigley, C 2019, ' Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort ', Alzheimer's and Dementia, vol. 15, no. 6, pp. 817-827 . https://doi.org/10.1016/j.jalz.2019.03.004, Alzheimer's & Dementia : the Journal of the Alzheimer's Association, Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2019, 15 (6), pp.817-827. ⟨10.1016/j.jalz.2019.03.004⟩, Alzheimer's & Dementia, Alzheimer's & Dementia, 2019, 15 (6), pp.817-827. ⟨10.1016/j.jalz.2019.03.004⟩, Alzheimer's and Dementia, 15(6), 817-827. Elsevier, Alzheimers & Dementia, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, Alzheimer's & dementia : the journal of the Alzheimer's Association, Alzheimer's & dementia, Kim, M, Snowden, S, Suvitaival, T, Ali, A, Merkler, D J, Ahmad, T, Westwood, S, Baird, A, Proitsi, P, Nevado-Holgado, A, Hye, A, Bos, I, Vos, S, Vandenberghe, R, Teunissen, C, Ten Kate, M, Scheltens, P, Gabel, S, Meersmans, K, Blin, O, Richardson, J, De Roeck, E, Sleegers, K, Bordet, R, Rami, L, Kettunen, P, Tsolaki, M, Verhey, F, Sala, I, Lléo, A, Peyratout, G, Tainta, M, Johannsen, P, Freund-Levi, Y, Frölich, L, Dobricic, V, Engelborghs, S, Frisoni, G B, Molinuevo, J L, Wallin, A, Popp, J, Martinez-Lage, P, Bertram, L, Barkhof, F, Ashton, N, Blennow, K, Zetterberg, H, Streffer, J, Visser, P J, Lovestone, S & Legido-Quigley, C 2019, ' Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort ', Alzheimer's & Dementia, vol. 15, no. 6, pp. 817-827 . https://doi.org/10.1016/j.jalz.2019.03.004, Alzheimer's & Dementia, Vol. 15, No 6 (2019) pp. 817-827, Alzheimer's & Dementia, 15(6), 817-827. Elsevier Science
- Publication Year :
- 2019
-
Abstract
- Introduction: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.Methods: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.Results: Eight metabolites were associated with amyloid b and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.Discussion: PFAMs have been found increased and associated with amyloid b burden in CSF and clinical measures. Crown Copyright (C) 2019 Published by Elsevier Inc. on behalf of the Alzheimer's Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/).
- Subjects :
- 0301 basic medicine
Oncology
Male
Neurology
Epidemiology
Neuropsychological Tests
Hippocampus
RECOMMENDATIONS
Cohort Studies
ddc:616.89
0302 clinical medicine
Cerebrospinal fluid
MARKERS
Biomarker discovery
Brain volume measurements
Medicine(all)
OLEAMIDE
biology
medicine.diagnostic_test
Health Policy
Brain
INDUCED LIPOKINE
EMIF-AD
Amyloidosis
Middle Aged
Alzheimer's disease
Magnetic Resonance Imaging
PERTURBATIONS
3. Good health
Psychiatry and Mental health
ACID
Female
Alzheimer’s disease
Life Sciences & Biomedicine
medicine.medical_specialty
Amyloid
Tau protein
Clinical Neurology
tau Proteins
CSF
METABOLISM
Article
Aged
Amyloid beta-Peptides/blood
Amyloid beta-Peptides/cerebrospinal fluid
Amyloidosis/blood
Amyloidosis/cerebrospinal fluid
Amyloidosis/metabolism
Biomarkers/blood
Biomarkers/cerebrospinal fluid
Brain/pathology
Cognitive Dysfunction/diagnosis
Hippocampus/metabolism
Humans
Memory/physiology
Metabolomics
tau Proteins/blood
tau Proteins/cerebrospinal fluid
Biomarkers
Cognitive function measurements
Dementia
Tau
03 medical and health sciences
Cellular and Molecular Neuroscience
Developmental Neuroscience
Memory
Internal medicine
12,13-DIHOME
medicine
13-DIHOME
Cognitive Dysfunction
BIOSYNTHESIS
Biology
Mini–Mental State Examination
Amyloid beta-Peptides
Science & Technology
business.industry
[SCCO.NEUR]Cognitive science/Neuroscience
[SCCO.NEUR] Cognitive science/Neuroscience
medicine.disease
030104 developmental biology
ddc:618.97
biology.protein
Human medicine
Neurology (clinical)
Neurosciences & Neurology
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 15525260 and 15525279
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & dementia, vol. 15, no. 6, pp. 817-827, Kim, M, Snowden, S, Suvitaival, T, Ali, A, Merkler, D J, Ahmad, T, Westwood, S, Baird, A, Proitsi, P, Nevado-Holgado, A, Hye, A, Bos, I, Vos, S, Vandenberghe, R, Teunissen, C, ten Kate, M, Scheltens, P, Gabel, S, Meersmans, K, Blin, O, Richardson, J, de Roeck, E, Sleegers, K, Bordet, R G, Rami, L, Kettunen, P, Tsolaki, M, Verhey, F, Sala, I, Lléo, A, Peyratout, G, Tainta, M, Johannsen, P, Freund-Levi, Y, Frölich, L, Dobricic, V, Engelborghs, S, Frisoni, G B, Molinuevo, J L, Wallin, A, Popp, J, Martinez-Lage, P, Bertram, L, Barkhof, F, Ashton, N, Blennow, K, Zetterberg, H, Streffer, J, Visser, P J, Lovestone, S & Legido-Quigley, C 2019, ' Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort ', Alzheimer's and Dementia, vol. 15, no. 6, pp. 817-827 . https://doi.org/10.1016/j.jalz.2019.03.004, Alzheimer's & Dementia : the Journal of the Alzheimer's Association, Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2019, 15 (6), pp.817-827. ⟨10.1016/j.jalz.2019.03.004⟩, Alzheimer's & Dementia, Alzheimer's & Dementia, 2019, 15 (6), pp.817-827. ⟨10.1016/j.jalz.2019.03.004⟩, Alzheimer's and Dementia, 15(6), 817-827. Elsevier, Alzheimers & Dementia, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, Alzheimer's & dementia : the journal of the Alzheimer's Association, Alzheimer's & dementia, Kim, M, Snowden, S, Suvitaival, T, Ali, A, Merkler, D J, Ahmad, T, Westwood, S, Baird, A, Proitsi, P, Nevado-Holgado, A, Hye, A, Bos, I, Vos, S, Vandenberghe, R, Teunissen, C, Ten Kate, M, Scheltens, P, Gabel, S, Meersmans, K, Blin, O, Richardson, J, De Roeck, E, Sleegers, K, Bordet, R, Rami, L, Kettunen, P, Tsolaki, M, Verhey, F, Sala, I, Lléo, A, Peyratout, G, Tainta, M, Johannsen, P, Freund-Levi, Y, Frölich, L, Dobricic, V, Engelborghs, S, Frisoni, G B, Molinuevo, J L, Wallin, A, Popp, J, Martinez-Lage, P, Bertram, L, Barkhof, F, Ashton, N, Blennow, K, Zetterberg, H, Streffer, J, Visser, P J, Lovestone, S & Legido-Quigley, C 2019, ' Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort ', Alzheimer's & Dementia, vol. 15, no. 6, pp. 817-827 . https://doi.org/10.1016/j.jalz.2019.03.004, Alzheimer's & Dementia, Vol. 15, No 6 (2019) pp. 817-827, Alzheimer's & Dementia, 15(6), 817-827. Elsevier Science
- Accession number :
- edsair.doi.dedup.....7566425c78fd543af6a31fa0be1388dc