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Hyperinsulinemia and blood pressure in non-obese middle-aged subjects with normal glucose tolerance

Hyperinsulinemia and blood pressure in non-obese middle-aged subjects with normal glucose tolerance

Authors :
Noriko Fujita
Kazuo Takebe
Tsuneharu Baba
T. Tomiyama
T. Kodama
Source :
The Tohoku journal of experimental medicine. 165(3)
Publication Year :
1991

Abstract

BABA, T., KODAMA, T., TOMIYAMA, T., FUJITA, N. and TAKEBE, K. Hyperinsulinemia and Blood Pressure in Non-obese Middle-aged Subjects with Normal Glucose Tolerance. Tohoku J. Exp. Med., 1991, 165 (3), 229-235-A possible link between hyperinsulinemia and blood pressure was studied in non-obese subjects with normal glucose tolerance. First, the responses in plasma glucose and serum insulin to an oral glucose load (75-g oral glucose tolerance test) were compared between 42 patients with essential hypertension and 93 normotensive control subjects. Second, of the 93 normotensive subjects, the relations of serum insulin levels to blood pressure, serum cholesterol, and triglycerides concentrations were assessed in 8 hyperinsulinemic (serum insulin level [during fasting, or after glucose loading, or both]>2 S.D. higher than the mean) and 8 pair-matched normoinsulinemic subjects (serum insulin level within 1 S.D, of the mean), individually matched for age, sex, and body mass index. Plasma glucose and serum insulin responses to the glucose load in hypertensive subjects were identical to the respective responses in normotensive subjects, while the mean total serum cholesterol level was slightly higher (p

Details

ISSN :
00408727
Volume :
165
Issue :
3
Database :
OpenAIRE
Journal :
The Tohoku journal of experimental medicine
Accession number :
edsair.doi.dedup.....756a3e170e6817da0763860597fdcf07