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Hyperinsulinemia and blood pressure in non-obese middle-aged subjects with normal glucose tolerance
Hyperinsulinemia and blood pressure in non-obese middle-aged subjects with normal glucose tolerance
- Source :
- The Tohoku journal of experimental medicine. 165(3)
- Publication Year :
- 1991
-
Abstract
- BABA, T., KODAMA, T., TOMIYAMA, T., FUJITA, N. and TAKEBE, K. Hyperinsulinemia and Blood Pressure in Non-obese Middle-aged Subjects with Normal Glucose Tolerance. Tohoku J. Exp. Med., 1991, 165 (3), 229-235-A possible link between hyperinsulinemia and blood pressure was studied in non-obese subjects with normal glucose tolerance. First, the responses in plasma glucose and serum insulin to an oral glucose load (75-g oral glucose tolerance test) were compared between 42 patients with essential hypertension and 93 normotensive control subjects. Second, of the 93 normotensive subjects, the relations of serum insulin levels to blood pressure, serum cholesterol, and triglycerides concentrations were assessed in 8 hyperinsulinemic (serum insulin level [during fasting, or after glucose loading, or both]>2 S.D. higher than the mean) and 8 pair-matched normoinsulinemic subjects (serum insulin level within 1 S.D, of the mean), individually matched for age, sex, and body mass index. Plasma glucose and serum insulin responses to the glucose load in hypertensive subjects were identical to the respective responses in normotensive subjects, while the mean total serum cholesterol level was slightly higher (p
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Diastole
Blood Pressure
Essential hypertension
General Biochemistry, Genetics and Molecular Biology
Body Mass Index
Insulin resistance
Non obese
Internal medicine
Hyperinsulinism
medicine
Hyperinsulinemia
Humans
Insulin
Normal glucose tolerance
business.industry
General Medicine
Glucose Tolerance Test
Middle Aged
medicine.disease
Lipids
Blood pressure
Endocrinology
Hypertension
Female
Insulin Resistance
business
Body mass index
Subjects
Details
- ISSN :
- 00408727
- Volume :
- 165
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Tohoku journal of experimental medicine
- Accession number :
- edsair.doi.dedup.....756a3e170e6817da0763860597fdcf07