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Metallo‐Helicoid with Double Rims: Polymerization Followed by Folding by Intramolecular Coordination

Authors :
Chung-Hao Liu
Yu Yan
Libin Ye
Jianxiang Huang
Sandra Khalife
Hai-Bo Yang
Tan Ji
Bingqian Xu
Shu-Ting Jiang
Mu-Ping Nieh
Guang-Qiang Yin
Heng Wang
Ruhong Zhou
Xiaopeng Li
Sneha Kandapal
Source :
Angewandte Chemie International Edition. 60:1281-1289
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

In this study, we established a feasible strategy to construct a new type of metallo-polymer with helicoidal structure through the combination of covalent polymerization and intramolecular coordination-driven self-assembly. In the design, a tetratopic monomer (M) was prepared with two terminal alkynes in the outer rim for polymerization, and two terpyridines (TPYs) in the inner rim for subsequent folding by selective intramolecular coordination. Then, the linear covalent polymer (P) was synthesized by polymerization of M via Glaser-Hay homocoupling reaction. Finally, intramolecular coordination interactions between TPYs and Zn(II) folded the backbone of P into a right- or left-handed metallo-helicoid (H) with double rims. Owing to multiple positive charges on the inner rim of helicoid, double-stranded DNA molecules (dsDNA) could interact with H through electrostatic interactions. Remarkably, dsDNA allowed exclusive formation of H with right handedness by means of chiral induction.

Details

ISSN :
15213773 and 14337851
Volume :
60
Database :
OpenAIRE
Journal :
Angewandte Chemie International Edition
Accession number :
edsair.doi.dedup.....7571e5a7895ce92ca782452d75a951ba
Full Text :
https://doi.org/10.1002/anie.202010696