Back to Search
Start Over
TCF7L2 polymorphisms, nut consumption, and the risk of metabolic syndrome: a prospective population based study
- Source :
- Nutrition & Metabolism, Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2020
-
Abstract
- Background The aim of this study was to investigate whether two variants of the TCF7L2 (rs7903146 and rs12255372) modify the association between nut consumption and the risk of metabolic syndrome (MetS). Additionally, the modifying effect of weight change during follow-up on these associations was investigated. Material and methods We prospectively studied 1423 participants of the Tehran Lipid and Glucose study aged 19–74 years who were followed-up for dietary assessment using a validated, semi-quantitative food frequency questionnaire. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for MetS events. Genotyping was performed by Human Omni Express-24-v1-0 chip. Results Over a median 8.9 years of follow-up, 415 new cases of MetS were documented. The median nut consumption was 20.0 g/week (Interquartile Range (IQR): 8.6–38.9 g/week). Regarding the rs7903146 genotype, in carriers of T allele (CT + TT), highest tertile of nut consumption was associated with a reduced risk of MetS after adjusting for confounders (HR: 0.67 (0.50–0.91)). Regarding the rs12255372 genotype, highest versus lowest tertile of nut consumption in participants with T allele (GT + TT) resulted in 34% reduction of MetS risk after adjustment for confounders (HR: 0.66 (0.49–0.69)). After stratification by weigh change ( Conclusion Higher consumption of nuts may reduces the risk of MetS in T-risk allele of the TCF7L2 rs7903146 and rs12255372 variants and weight change may modify this association.
- Subjects :
- medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
TCF7L2 polymorphisms
lcsh:TX341-641
030209 endocrinology & metabolism
03 medical and health sciences
0302 clinical medicine
Interquartile range
Internal medicine
Gene-diet interaction
Medicine
Nuts
030212 general & internal medicine
lcsh:RC620-627
Nutrition and Dietetics
business.industry
Proportional hazards model
Research
Weight change
Confounding
Hazard ratio
medicine.disease
Metabolic syndrome
lcsh:Nutritional diseases. Deficiency diseases
medicine.symptom
business
lcsh:Nutrition. Foods and food supply
Weight gain
TCF7L2
Subjects
Details
- ISSN :
- 17437075
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nutritionmetabolism
- Accession number :
- edsair.doi.dedup.....75723cb272fd2a988ca305fb9122df07