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No SARS‐CoV ‐2 antibody response in 25 patients with pseudo‐chilblains
- Source :
- Dermatologic Therapy
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Chilblain‐like acral lesions have been identified in some coronavirus disease 2019 (COVID‐19) patients. It has been suggested that these pseudo‐chilblains could be a specific marker of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Most patients with these lesions have had negative polymerase chain reactions (PCRs), but some authors believe serology tests are likely to give positive results. We designed a prospective study including all patients with pseudo‐chilblains treated in outpatient department in April and May 2020 and then performed SARS‐CoV‐2 PCR and serology tests on all available patients. We evaluated 59 patients, of whom 17 had undergone PCR before the study period, all with negative results. For the present study, we performed 20 additional PCRs, serology tests in 25 patients, and a parvovirus B19 antibody test in 15 patients. All results were negative. Our findings counter the hypothesis that serology is likely to reveal SARS‐CoV‐2 infection in patients with pseudo‐chilblains. One hypothesis for our negative results is that the time period between symptom onset and antibody production is longer in these patients; another is that the lesions are caused by behavioral changes during lockdown rather than SARS‐CoV‐2 infection. We nevertheless maintain that COVID‐19 should be ruled out in people presenting with chilblain‐like lesions.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Adolescent
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
coronavirus
Dermatology
medicine.disease_cause
Polymerase Chain Reaction
chilblains
SARS‐CoV‐2
Serology
Short Papers
Young Adult
030207 dermatology & venereal diseases
03 medical and health sciences
COVID-19 Testing
0302 clinical medicine
COVID‐19
Internal medicine
medicine
Short Paper
Humans
Outpatient clinic
Prospective Studies
Child
Chilblains
Prospective cohort study
Coronavirus
acral
SARS-CoV-2
business.industry
COVID-19
Infant
virus diseases
General Medicine
Middle Aged
medicine.disease
Antibody response
Child, Preschool
030220 oncology & carcinogenesis
Antibody Formation
Quarantine
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 15298019 and 13960296
- Database :
- OpenAIRE
- Journal :
- Dermatologic Therapy
- Accession number :
- edsair.doi.dedup.....75789fe850b21bc48890b77bcfe3384a
- Full Text :
- https://doi.org/10.1111/dth.14332