Back to Search
Start Over
The origin of island populations of the African malaria mosquito, Anopheles coluzzii
- Source :
- Communications Biology, Communications biology, vol 4, iss 1, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
- Publication Year :
- 2021
-
Abstract
- Anopheles coluzzii is a major malaria vector throughout its distribution in west-central Africa. Here we present a whole-genome study of 142 specimens from nine countries in continental Africa and three islands in the Gulf of Guinea. This sample set covers a large part of this species’ geographic range. Our population genomic analyses included a description of the structure of mainland populations, island populations, and connectivity between them. Three genetic clusters are identified among mainland populations and genetic distances (FST) fits an isolation-by-distance model. Genomic analyses are applied to estimate the demographic history and ancestry for each island. Taken together with the unique biogeography and history of human occupation for each island, they present a coherent explanation underlying levels of genetic isolation between mainland and island populations. We discuss the relationship of our findings to the suitability of São Tomé and Príncipe islands as candidate sites for potential field trials of genetic-based malaria control strategies.<br />Campos, Lanzaro and colleagues use whole-genome sequencing and population genomic analyses to infer connectivity between mainland and island mosquito populations in West Africa. The unique biogeographic history for each island population is reported, and the findings highlight potential candidate sites for genetic-based malaria control strategies.
- Subjects :
- 0106 biological sciences
0301 basic medicine
and promotion of well-being
Population genetics
Medicine (miscellaneous)
Distribution (economics)
01 natural sciences
Biology (General)
SDG 15 - Life on Land
Islands
education.field_of_study
Ecology
Biological Evolution
Anopheles coluzzii
Phylogeography
Geography
Infectious Diseases
Mainland
General Agricultural and Biological Sciences
Infection
Genetic isolate
QH301-705.5
Demographic history
Evolution
Biogeography
Population
malaria
Mosquito Vectors
010603 evolutionary biology
General Biochemistry, Genetics and Molecular Biology
Article
Evolution, Molecular
03 medical and health sciences
Rare Diseases
SDG 3 - Good Health and Well-being
parasitic diseases
Anopheles
medicine
Genetics
Animals
education
Island malaria
Ecology, Evolution, Behavior and Systematics
3.2 Interventions to alter physical and biological environmental risks
Whole Genome Sequencing
business.industry
Human Genome
African
Molecular
Genetic Variation
medicine.disease
Prevention of disease and conditions
Malaria
Vector-Borne Diseases
030104 developmental biology
Good Health and Well Being
Genetics, Population
Insect Science
Africa
business
Subjects
Details
- ISSN :
- 23993642
- Volume :
- 4
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Communications biology
- Accession number :
- edsair.doi.dedup.....75998cf53525d5799c122e04b40b63f4