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Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
- Source :
- Nature Neuroscience, Nature Neuroscience, Nature Publishing Group, 2016, 19 (3), pp.420-431. ⟨10.1038/nn.4228⟩, Nature neuroscience, 19(3), 420-431. NATURE AMERICA INC, Nature neuroscience, Nature Neuroscience, 19(3), 420. Nature Publishing Group, Franke, B, Stein, J L, Ripke, S, Anttila, V, Hibar, D P, van Hulzen, K J E, Arias-Vasquez, A, Smoller, J W, Nichols, T E, Neale, M C, McIntosh, A M, Lee, P, McMahon, F J, Meyer-Lindenberg, A, Mattheisen, M, Andreassen, O A, Gruber, O, Sachdev, P S, Roiz-Santiañez, R, Saykin, A J, Ehrlich, S, Mather, K A, Turner, J A, Schwarz, E, Thalamuthu, A, Yao, Y, Ho, Y Y W, Martin, N G, Wright, M J, O'Donovan, M C, Thompson, P M & Neale, B M & Medland, S E & Sullivan, P F 2016, ' Genetic influences on schizophrenia and subcortical brain volumes : Large-scale proof of concept ', Nature Neuroscience, vol. 19, no. 3, pp. 420–431 . https://doi.org/10.1038/nn.4228, Nature Neuroscience, 2016, 19 (3), pp.420-431. ⟨10.1038/nn.4228⟩, Nature neuroscience, vol 19, iss 3, Nature Neuroscience, 19, 420-31, Franke, B, Stein, J L, Ripke, S, Anttila, V, Hibar, D P, van Hulzen, K J E, Arias-Vasquez, A, Smoller, J W, Nichols, T E, Neale, M C, McIntosh, A M, Lee, P, McMahon, F J, Meyer-Lindenberg, A, Mattheisen, M, Andreassen, O A, Gruber, O, Sachdev, P S, Roiz-Santiañez, R, Saykin, A J, Ehrlich, S, Mather, K A, Turner, J A, Schwarz, E, Thalamuthu, A, Yao, Y, Ho, Y Y W, Martin, N G, Wright, M J, O'Donovan, M C, Thompson, P M, Neale, B M, Medland, S E, Sullivan, P F & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2016, ' Genetic influences on schizophrenia and subcortical brain volumes : large-scale proof of concept ', Nature Neuroscience, vol. 19, no. 3, pp. 420-31 . https://doi.org/10.1038/nn.4228, Franke, Barbara; Franke, Barbara; Stein, Jason L; Ripke, Stephan; Anttila, Verneri; Hibar, Derrek P; et al.(2016). Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.. Nature neuroscience, 19(3), 420-431. doi: 10.1038/nn.4228. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/96n5p3jc, Nature Neuroscience, 19, 3, pp. 420-31, Nature reviews / Neuroscience 19(3), 420-431 (2016). doi:10.1038/nn.4228, Nature Neuroscience, 19(3), 420-431. Nature Publishing Group, Nature neuroscience, 19(3), 420-+. Nature Publishing Group, Franke, B, Stein, J L, Ripke, S, Anttila, V, Hibar, D P, van Hulzen, K J E, Arias-Vasquez, A, Smoller, J W, Nichols, T E, Neale, M C, McIntosh, A M, Lee, P, McMahon, F J, Meyer-Lindenberg, A, Mattheisen, M, Andreassen, O A, Gruber, O, Sachdev, P S, Roiz-Santiañez, R, Saykin, A J, Ehrlich, S, Mather, K A, Turner, J A, Schwarz, E, Thalamuthu, A, Yao, Y, Ho, Y Y W, Martin, N G, Wright, M J, den Braber, A, Fedko, I O, Hottenga, J J, van t Ent, D, Boomsma, D I, de Geus, E J C, O'Donovan, M C, Thompson, P M, Neale, B M, Medland, S E & Sullivan, P F 2016, ' Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept ', Nature Neuroscience, vol. 19, no. 3, pp. 420-431 . https://doi.org/10.1038/nn.4228
- Publication Year :
- 2016
-
Abstract
- Article<br />Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.<br />final draft<br />peerReviewed
- Subjects :
- 0301 basic medicine
Netherlands Twin Register (NTR)
genetic association
Genome-wide association study
brain imaging
VARIANTS
Genome-wide association studies
Linkage Disequilibrium
0302 clinical medicine
pathology [Brain]
2.1 Biological and endogenous factors
Psychology
GWAS
genetics [Schizophrenia]
genetics
genetics [Genetic Predisposition to Disease]
Aetiology
Non-U.S. Gov't
PERSPECTIVE
humans
Schizophrenia Working Group of the Psychiatric Genomics Consortium
neuroimaging
General Neuroscience
Research Support, Non-U.S. Gov't
Brain
Single Nucleotide
Organ Size
Endophenotypes
Genetic Predisposition to Disease
Humans
Magnetic Resonance Imaging
Neuroimaging
Polymorphism, Single Nucleotide
Schizophrenia
Genome-Wide Association Study
Neuroscience (all)
Serious Mental Illness
ENIGMA Consortium
3. Good health
endophenotype
Mental Health
Meta-analysis
Neurological
genetics [Polymorphism, Single Nucleotide]
Cognitive Sciences
MRI
Neuroinformatics
DISORDERS
heredity
Schizophrenia (object-oriented programming)
brain
Non-P.H.S
Brain Structure and Function
RELATIVES
PHENOTYPES
Research Support
N.I.H
03 medical and health sciences
Magnetic resonance imaging
ENDOPHENOTYPE
Research Support, N.I.H., Extramural
ddc:570
Journal Article
Polymorphism
GENOME-WIDE ASSOCIATION
pathology [Schizophrenia]
METAANALYSIS
genetic predisposition to disease
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
Neurology & Neurosurgery
genome-wide association study
[SCCO.NEUR]Cognitive science/Neuroscience
Human Genome
Neurosciences
Extramural
Genetic architecture
Brain Disorders
meta-analysis
schizophrenia
INDIVIDUALS
030104 developmental biology
Genetic marker
Endophenotype
DISCOVERY
Genetic markers
U.S. Gov't
Human medicine
Neuroscience
genetic predisposition
030217 neurology & neurosurgery
Research Support, U.S. Gov't, Non-P.H.S
Meta-Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 10976256 and 15461726
- Volume :
- 19
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Nature Neuroscience
- Accession number :
- edsair.doi.dedup.....75abe69dc9a38a3f7eb3f2ba816e730f