Back to Search
Start Over
Cholesteatoma Prevention by Local Treatment with Vitamin A
- Source :
- Otology & Neurotology. 22:576-578
- Publication Year :
- 2001
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2001.
-
Abstract
- Hypothesis: In view of the proven effectiveness of vitamin A for the treatment of hyperkeratosis, it was hypothesized that vitamin A may also be a feasible therapeutic option for cholesteatoma, which has similar histologic features. Background: Cholesteatoma is a major cause of chronic ear disease, often requiring surgery. The recurrence rate may exceed 20%. Hyperkeratosis is a major sequela of tympanomastoid surgery, causing chronic ear hygiene problems. Methods: The external auditory canals of 40 Mongolian gerbils were ligated to induce cholesteatomas. The ears were divided into three groups by type of treatment: group I, vitamin A drops (n = 40); group II, Cortisporin drops (n = 20); group III, no treatment (control subjects) (n = 20). Examination for the development and grade of cholesteatomas was performed after 9 months. Results: Cholesteatomas developed in 26 ears (65%) of group I, 12 ears (60%) of group II, and 20 ears (100%) of group III. The differences were significant between groups I and III and groups II and III for both rate of cholesteatomas and severity of grade. There were no significant differences between groups I and II. Conclusion: Local treatment reduces the risk of cholesteatomas in ligated gerbilline ears. Cortisporin and vitamin A are equally effective as local treatments.
- Subjects :
- Vitamin
medicine.medical_specialty
Hydrocortisone
Hyperkeratosis
Cortisporin
chemistry.chemical_compound
Route of administration
otorhinolaryngologic diseases
medicine
Animals
Postoperative Period
Vitamin A
Polymyxin B
Cholesteatoma, Middle Ear
business.industry
Retinol
Cholesteatoma
Neomycin
Sequela
medicine.disease
Sensory Systems
Dyskeratosis
Surgery
Drug Combinations
Otorhinolaryngology
chemistry
sense organs
Neurology (clinical)
medicine.drug_brand
Gerbillinae
business
Subjects
Details
- ISSN :
- 15317129
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Otology & Neurotology
- Accession number :
- edsair.doi.dedup.....75ad02673fbbfb8d538449f850579579