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Associations of airway inflammation and responsiveness markers in non asthmatic subjects at start of apprenticeship

Authors :
Valérie Demange
Pascal Wild
A. Barbaud
Denis Zmirou-Navier
Paul Tossa
Abraham Bohadana
Christophe Paris
Département épidémiologie en entreprise (EE)
Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy))
Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)
École des Hautes Études en Santé Publique [EHESP] (EHESP)
Centre antipoison et de toxicovigilance (Nancy) (CAPTV Nancy)
Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)
Service de Pneumologie [CHRU Nancy]
Service de Dermatologie et Allergologie [CHRU Nancy]
This study was financed through grants awarded by AFSSET [Agence Française de Sécurité Sanitaire de l'Environnement et du Travail contract RD-2003-04], the French Ministry of Labour (2002 Health and Occupation call for tenders), the regional health insurance fund (CRAM Nord-Est), the Lorraine Region, ANR [French National Research Agency
grant 05 9 75/ANR 05 SEST 021-01] and by INRS. The Soufflet group and L'Oréal also provided financial support. Dr Tossa was recipient of a doctorate grant awarded by the Lorraine Region.
BMC, Ed.
Source :
BMC Pulmonary Medicine, BMC Pulmonary Medicine, BioMed Central, 2010, 10 (1), pp.37. ⟨10.1186/1471-2466-10-37⟩, BMC Pulmonary Medicine, Vol 10, Iss 1, p 37 (2010)
Publication Year :
2010
Publisher :
HAL CCSD, 2010.

Abstract

Background Bronchial Hyperresponsiveness (BHR) is considered a hallmark of asthma. Other methods are helpful in epidemiological respiratory health studies including Fractional Exhaled Nitric Oxide (FENO) and Eosinophils Percentage (EP) in nasal lavage fluid measuring markers for airway inflammation along with the Forced Oscillatory Technique measuring Airway resistance (AR). Can their outcomes discriminate profiles of respiratory health in healthy subjects starting apprenticeship in occupations with a risk of asthma? Methods Rhinoconjunctivitis, asthma-like symptoms, FEV1 and AR post-Methacholine Bronchial Challenge (MBC) test results, FENO measurements and EP were all investigated in apprentice bakers, pastry-makers and hairdressers not suffering from asthma. Multiple Correspondence Analysis (MCA) was simultaneously conducted in relation to these groups and this generated a synthetic partition (EI). Associations between groups of subjects based on BHR and EI respectively, as well as risk factors, symptoms and investigations were also assessed. Results Among the 441 apprentice subjects, 45 (10%) declared rhinoconjunctivitis-like symptoms, 18 (4%) declared asthma-like symptoms and 26 (6%) suffered from BHR. The mean increase in AR post-MBC test was 21% (sd = 20.8%). The median of FENO values was 12.6 ppb (2.6-132 range). Twenty-six subjects (6.7%) had EP exceeding 14%. BHR was associated with atopy (p < 0.01) and highest FENO values (p = 0.09). EI identified 39 subjects with eosinophilic inflammation (highest values of FENO and eosinophils), which was associated with BHR and atopy. Conclusions Are any of the identified markers predictive of increased inflammatory responsiveness or of development of symptoms caused by occupational exposures? Analysis of population follow-up will attempt to answer this question.

Details

Language :
English
ISSN :
14712466
Database :
OpenAIRE
Journal :
BMC Pulmonary Medicine, BMC Pulmonary Medicine, BioMed Central, 2010, 10 (1), pp.37. ⟨10.1186/1471-2466-10-37⟩, BMC Pulmonary Medicine, Vol 10, Iss 1, p 37 (2010)
Accession number :
edsair.doi.dedup.....75b71d4526826f57bf7ae9299b56caa6
Full Text :
https://doi.org/10.1186/1471-2466-10-37⟩