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Topoisomerase II alpha and telomerase expression in papillary thyroid carcinomas
- Source :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 30(1)
- Publication Year :
- 2004
-
Abstract
- Background. Altered topoisomerase II α (Topo II α) expression and telomerase activity (TA) reflect tumour cell growth and malignant transformation. Methods. We examined TA by using a TRAP assay and expression of Topo II α by immunohistochemical analysis in a series of 27 cases of papillary thyroid carcinoma (PTC). Results. Topo II α labelling index (LI) ranged from 0.1 to 4.2% and was significantly associated with patient age ( r =−0.42, p =0.003), with higher levels of Topo II α in patients under 40 years. There was no relationship between Topo II α LI, AGES score or other clinical outcome. TA was detected in 14 PTC, with relative levels ranging from 1.2 to 102 units. A significant positive correlation between the multiplicity of tumoral foci and the TA levels ( p −2 ) was noted. Conclusion. We concluded that Topo II α cannot be used as a marker of tumour aggressiveness. Furthermore, enhanced Topo II α expression in PTCs from patients less than 40 years old suggests that this age group might benefit from Topo II inhibitor chemotherapy.
- Subjects :
- Adult
medicine.medical_specialty
Telomerase
medicine.medical_treatment
Malignant transformation
Thyroid carcinoma
Antigens, Neoplasm
Internal medicine
medicine
Carcinoma
Neoplasm
Humans
Thyroid Neoplasms
Aged
Chemotherapy
Cell growth
business.industry
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
Carcinoma, Papillary
DNA-Binding Proteins
Endocrinology
DNA Topoisomerases, Type II
Oncology
Cancer research
Surgery
business
Subjects
Details
- ISSN :
- 07487983
- Volume :
- 30
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....75c5395e89d32012eba42eeac5203425