Back to Search
Start Over
CD44: a validated target for improved delivery of cancer therapeutics
- Source :
- Expert Opinion on Therapeutic Targets. 16:635-650
- Publication Year :
- 2012
- Publisher :
- Informa UK Limited, 2012.
-
Abstract
- Advances in cancer therapeutics, namely more effective and less toxic treatments, will occur with targeting strategies that enhance the tumor biodistribution and thwart normal tissue exposure of the drug. This review focuses on cancer drug targeting approaches that exploit the expression of the cell-surface proteoglycan family, CD44, on the tumor cell surface followed by some form of ligand binding and induced CD44 internalization and intracellular drug release: in effect using this as a 'Trojan Horse' to more selectively access tumor cells.This review defines the origins of evidence for a linkage between CD44 expression and malignancy, and invokes contemporary views of the importance of putative CD44(+) cancer stem cells in disease resistance. Although the primary emphasis is on the most advanced and developed paths, those that have either made it to the clinic or are well-poised to get there, a wide scope of additional approaches at various preclinical stages is also briefly reviewed.The future should see development of drug targeting approaches that exploit CD44 expression on CSCs/TICs, including applications to cytotoxic agents currently in the clinic.
- Subjects :
- Drug
Biodistribution
media_common.quotation_subject
Clinical Biochemistry
Antineoplastic Agents
Plasma protein binding
Pharmacology
Malignancy
Cancer stem cell
Neoplasms
Drug Discovery
medicine
Animals
Humans
Molecular Targeted Therapy
Hyaluronic Acid
Internalization
media_common
Drug Carriers
biology
CD44
Cancer
medicine.disease
Hyaluronan Receptors
biology.protein
Cancer research
Molecular Medicine
Protein Binding
Subjects
Details
- ISSN :
- 17447631 and 14728222
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Expert Opinion on Therapeutic Targets
- Accession number :
- edsair.doi.dedup.....75d61f66aed0a62f95356af550b99a33
- Full Text :
- https://doi.org/10.1517/14728222.2012.687374