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Quantifying intraepithelial lymphocytes and subepithelial collagen band in microscopic colitis, extracting insights into the interrelationship of lymphocytic and collagenous colitis
- Source :
- Annals of Diagnostic Pathology. 52:151741
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Microscopic colitis (MC) is the umbrella term for the conditions termed lymphocytic colitis (LC) and collagenous colitis (CC). LC with thickening of the subepithelial collagen band or CC with increased number of intraepithelial T- lymphocytes (IELs) is often seen in MC and may lead to difficulties in correct histological classification. We investigated the extent of overlapping features of CC and LC in 60 cases of MC by measuring the exact thickness of the subepithelial collagen band in Van Gieson stained slides and quantifying number of IELs in CD3 stained slides by digital image analysis. A thickened collagen band was observed in nine out of 29 cases with LC (31%) and an increased number of IELs in all 23 cases of CC (100%). There was no correlation between the thickness of the collagen band and number of IELs. Due to the increased number of IELs in all cases of CC we consider the lymphocytic inflammatory infiltration of the mucosa to be the essential histopathological feature of MC. However, although LC and CC are related due to the lymphocytic inflammation, the non-linear correlation of number of IELs and thickness of the collagenous band indicate differences in their pathogenesis.
- Subjects :
- Colitis, Lymphocytic
0301 basic medicine
Pathology
medicine.medical_specialty
Lymphocytic colitis
CD3
Colitis, Collagenous
digestive system
Pathology and Forensic Medicine
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Microscopic colitis
Image Processing, Computer-Assisted
medicine
Van Gieson's stain
Humans
Lymphocytes
Intraepithelial Lymphocytes
Observer Variation
Collagenous colitis
biology
Chemistry
Histology
General Medicine
medicine.disease
Colitis, Microscopic
030104 developmental biology
030220 oncology & carcinogenesis
biology.protein
Intraepithelial lymphocyte
Collagen
Subjects
Details
- ISSN :
- 10929134
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Annals of Diagnostic Pathology
- Accession number :
- edsair.doi.dedup.....760136965ef26b35bc50cca94187d8dc