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Predictors of COVID-19 in an outpatient fever clinic
- Source :
- PLoS ONE, Vol 16, Iss 7, p e0254990 (2021), PLoS ONE
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Background The objective of this study was to identify clinical risk factors for COVID-19 in a German outpatient fever clinic that allow distinction of SARS-CoV-2 infected patients from other patients with flu-like symptoms. Methods This is a retrospective, single-centre cohort study. Patients were included visiting the fever clinic from 4th of April 2020 to 15th of May 2020. Symptoms, comorbidities, and socio-demographic factors were recorded in a standardized fashion. Multivariate logistic regression was used to identify risk factors of COVID-19, on the bases of those a model discrimination was assessed using area under the receiver operation curves (AUROC). Results The final analysis included 930 patients, of which 74 (8%) had COVID-19. Anosmia (OR 10.71; CI 6.07–18.9) and ageusia (OR 9.3; CI 5.36–16.12) were strongly associated with COVID-19. High-risk exposure (OR 12.20; CI 6.80–21.90), especially in the same household (OR 4.14; CI 1.28–13.33), was also correlated; the more household members, especially with flu-like symptoms, the higher the risk of COVID-19. Working in an essential workplace was also associated with COVID-19 (OR 2.35; CI 1.40–3.96), whereas smoking was inversely correlated (OR 0.19; CI 0.08–0.44). A model that considered risk factors like anosmia, ageusia, concomitant of symptomatic household members and smoking well discriminated COVID-19 patients from other patients with flu-like symptoms (AUROC 0.84). Conclusions We report a set of four readily available clinical parameters that allow the identification of high-risk individuals of COVID-19. Our study will not replace molecular testing but will help guide containment efforts while waiting for test results.
- Subjects :
- 0301 basic medicine
Male
RNA viruses
Viral Diseases
Pulmonology
Epidemiology
Coronaviruses
Fevers
Social Sciences
Logistic regression
Ambulatory Care Facilities
Cohort Studies
Habits
0302 clinical medicine
Medical Conditions
Medicine and Health Sciences
Smoking Habits
Medicine
Psychology
Public and Occupational Health
030212 general & internal medicine
Pathology and laboratory medicine
Virus Testing
Multidisciplinary
Middle Aged
Medical microbiology
Infectious Diseases
Viruses
Engineering and Technology
Female
Safety Equipment
medicine.symptom
SARS CoV 2
Pathogens
Safety
Risk assessment
Cohort study
Research Article
Adult
medicine.medical_specialty
Fever
SARS coronavirus
Science
Anosmia
MEDLINE
Equipment
Risk Assessment
Microbiology
03 medical and health sciences
Respiratory Disorders
Signs and Symptoms
Diagnostic Medicine
Internal medicine
Humans
Pandemics
Retrospective Studies
Behavior
Models, Statistical
Biology and life sciences
business.industry
Organisms
Viral pathogens
COVID-19
Retrospective cohort study
Covid 19
Ageusia
Microbial pathogens
030104 developmental biology
Concomitant
Medical Risk Factors
Respiratory Infections
Clinical Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....7601b4482f25f16f8d575c04dc05aafa