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Moxibustion-Simulating Bipolar Radiofrequency Suppresses Weight Gain and Induces Adipose Tissue Browning via Activation of UCP1 and FGF21 in a Mouse Model of Diet-Induced Obesity
- Source :
- Evidence-Based Complementary and Alternative Medicine, Vol 2018 (2018), Evidence-based Complementary and Alternative Medicine : eCAM
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- Background. Obesity is a pathological condition associated with various diseases including diabetes, stroke, arthritis, infertility, and heart disease. Moxibustion is widely used to prevent and manage obesity in traditional Asian medicine. We tested our hypothesis that moxibustion-simulating bipolar radiofrequency (M-RF) can suppress total body and white adipose tissue (WAT) weight gain via induction of WAT browning in a mouse model of diet-induced obesity (DIO). Methods. We designed an M-RF device that could accurately adjust the depth and temperature at which heat stimulation was administered into the abdomen of DIO mice. High-fat-fed male C57BL/6 mice were treated with the M-RF device every two or three days for three weeks. We then harvested WAT and serum from the mice and measured total body and WAT weight, size of adipocytes, mitochondrial contents, features of the dead adipocyte environment, and levels of uncoupling protein 1 (UCP1) and fibroblast growth factor 21 (FGF21). Results. Heat stimulation by M-RF in DIO mice resulted in precise temperature adjustment in the mice abdomen, with variance less than 1°C. Additionally, M-RF stimulation inhibited body and WAT weight gain, resulting in increased formation of beige adipocytes, increased mitochondrial content, and decreased formation of dead adipocytes in WAT. Moreover, treatment of M-RF induced expression of UCP1 and FGF21 in serum and/or epididymal WATs in DIO mice. Conclusion. Heat stimulation by M-RF treatment induced upregulation of UCP1 and FGF21 expression in serum and/or WATs, which was correlated with reduced total body and WAT weight gain in DIO mice.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
FGF21
Article Subject
Adipose tissue
Stimulation
White adipose tissue
03 medical and health sciences
chemistry.chemical_compound
Adipocyte
Internal medicine
Diabetes mellitus
medicine
business.industry
food and beverages
nutritional and metabolic diseases
lcsh:Other systems of medicine
medicine.disease
lcsh:RZ201-999
Thermogenin
030104 developmental biology
Endocrinology
Complementary and alternative medicine
chemistry
medicine.symptom
business
Weight gain
hormones, hormone substitutes, and hormone antagonists
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 17414288
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Evidence-Based Complementary and Alternative Medicine
- Accession number :
- edsair.doi.dedup.....7612ae0282a17276aa5bedb54ce370be