Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2

Authors :: Wenying Yu
Yucheng Zhao
Hui Ye
Nanping Wu
Yixian Liao
Nannan Chen
Zhiling Li
Ning Wan
Haiping Hao
Honggao Yan
Yibei Xiao
Maode Lai
Source :: Journal of medicinal chemistry. 65(24)
Publication Year :: 2022
Abstract: The two proteases, PL

Subjects :: SARS-CoV-2
Viral Proteases
COVID-19
Viral Nonstructural Proteins
Antiviral Agents
Rats
Molecular Docking Simulation
Mice
Cysteine Endopeptidases
Drug Discovery
Papain
Molecular Medicine
Animals
Protease Inhibitors
Peptide Hydrolases

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