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Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies
- Source :
- Journal of Cellular and Molecular Medicine
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Recent advances in skin-resident adult stem/progenitor cell research have revealed that these immature and regenerative cells with a high longevity provide critical functions in maintaining skin homeostasis and repair after severe injuries along the lifespan of individuals. The establishment of the functional properties of distinct adult stem/progenitor cells found in skin epidermis and hair follicles and extrinsic signals from their niches, which are deregulated during their aging and malignant transformation, has significantly improved our understanding on the etiopathogenesis of diverse human skin disorders and cancers. Particularly, enhanced ultraviolet radiation exposure, inflammation and oxidative stress and telomere attrition during chronological aging may induce severe DNA damages and genomic instability in the skin-resident stem/progenitor cells and their progenies. These molecular events may result in the alterations in key signalling components controlling their self-renewal and/or regenerative capacities as well as the activation of tumour suppressor gene products that trigger their growth arrest and senescence or apoptotic death. The progressive decline in the regenerative functions and/or number of skin-resident adult stem/progenitor cells may cause diverse skin diseases with advancing age. Moreover, the photoaging, telomerase re-activation and occurrence of different oncogenic events in skin-resident adult stem/progenitor cells may also culminate in their malignant transformation into cancer stem/progenitor cells and skin cancer initiation and progression. Therefore, the anti-inflammatory and anti-oxidant treatments and stem cell-replacement and gene therapies as well as the molecular targeting of their malignant counterpart, skin cancer-initiating cells offer great promise to treat diverse skin disorders and cancers.
- Subjects :
- molecular targeting
Telomerase
Skin Neoplasms
senescence
Stem cell theory of aging
Cell- and Tissue-Based Therapy
Reviews
Antineoplastic Agents
Biology
skin cancer stem/progenitor cells
03 medical and health sciences
0302 clinical medicine
Cancer stem cell
Skin Physiological Phenomena
medicine
Animals
Humans
Regeneration
anti-aging therapies
Progenitor cell
Melanoma
Cellular Senescence
Skin
030304 developmental biology
0303 health sciences
integumentary system
Stem Cells
aging
Cell Biology
cancer therapies
medicine.disease
3. Good health
Endothelial stem cell
Disease Models, Animal
030220 oncology & carcinogenesis
skin-resident adult stem/progenitor cells
Immunology
Cancer research
Molecular Medicine
Stem cell
Skin cancer
Cell aging
Signal Transduction
Subjects
Details
- ISSN :
- 15821838
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular and Molecular Medicine
- Accession number :
- edsair.doi.dedup.....7627b1e8573b2560fa04586035e9b3b7
- Full Text :
- https://doi.org/10.1111/j.1582-4934.2009.00885.x