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Contribution of Central Nitric Oxide to the Regulation of Blood Pressure and Sodium Balance in DOCA-salt Hypertension
- Source :
- Journal of Cardiovascular Pharmacology. 47:680-685
- Publication Year :
- 2006
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2006.
-
Abstract
- We examined whether central nitric oxide is involved in blood pressure (BP) regulation in deoxycorticosterone acetate (DOCA)-salt hypertension. DOCA-salt rats were intracerebroventricularly infused (ICV) NG-monomethyl L-arginine (L-NMMA) for 4 weeks at either low (0.08 mg/kg/d; n = 8) or high (0.16 mg/kg/d; n = 8) dose. Saline ICV (n = 9) and intraperitoneal infused L-NMMA (low, n = 6; high dose, n = 6) were served as controls. Also, L-NMMA ICV (low, n = 6; high dose, n = 6) was conducted in normal rats. At week 3 and after, DOCA-salt with low L-NMMA ICV showed a higher BP than saline ICV (at week 4: 167.4 +/- 3.6 vs. 150.3 +/- 3.9 mm Hg, P < 0.01); this difference of BP was cancelled after ganglionic block. High L-NMMA ICV did not affect the trend of BP; however, it caused a reduced amount of saline drinking and a less estimated sodium retention than saline or low L-NMMA ICV (for 3 wk; 47.5 +/- 1.1 vs. 66.0 +/- 3.7 and 61.7 +/- 2.5 mmol, P < 0.01). In normal rats, high, but not low, L-NMMA ICV elevated BP with no effect on drinking behavior. Intraperitoneal infused L-NMMA did not affect the development of hypertension and/or sodium balance. These data suggested that, in DOCA-salt, central nitric oxide is involved in BP regulation through the dual action on sympathetic nervous activity and sodium balance.
- Subjects :
- Male
medicine.medical_specialty
Ganglionic Blockers
medicine.medical_treatment
Sodium
Drinking
Ganglionic blocker
chemistry.chemical_element
Blood Pressure
Sodium Chloride
Nitric Oxide
Hexamethonium
Nitric oxide
Eating
Norepinephrine
chemistry.chemical_compound
Internal medicine
Renin
Renin–angiotensin system
medicine
Animals
Enzyme Inhibitors
Rats, Wistar
Desoxycorticosterone
Saline
Pharmacology
omega-N-Methylarginine
biology
Rats
Arginine Vasopressin
Nitric oxide synthase
Endocrinology
Blood pressure
chemistry
Hypertension
biology.protein
Omega-N-Methylarginine
Nitric Oxide Synthase
Cardiology and Cardiovascular Medicine
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 01602446
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Pharmacology
- Accession number :
- edsair.doi.dedup.....763eb91bd8cde1343697e2edc7769ca8