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Cross-Cultural Longitudinal Study on Cognitive Decline (CLoCODE) for Subjective Cognitive Decline in China and Germany: A Protocol for Study Design
- Source :
- Journal of Alzheimer's disease 87(3), 1319-1333 (2022). doi:10.3233/JAD-215452
- Publication Year :
- 2022
-
Abstract
- Background: Subjective cognitive decline (SCD) is considered as the first symptomatic manifestation of Alzheimer’s disease (AD), which is also affected by different cultural backgrounds. Establishing cross-cultural prediction models of SCD is challenging. Objective: To establish prediction models of SCD available for both the Chinese and European populations. Methods: In this project, 330 SCD from China and 380 SCD from Germany are intended to be recruited. For all participants, standardized assessments, including clinical, neuropsychological, apolipoprotein E (APOE) genotype, blood, and multi-parameter magnetic resonance imaging (MRI) at baseline will be conducted. Participants will voluntarily undergo amyloid positron emission tomography (PET) and are classified into amyloid-β (Aβ) positive SCD (SCD+) and Aβ negative SCD (SCD-). First, baseline data of all SCD individuals between the two cohorts will be compared. Then, key features associated with brain amyloidosis will be extracted in SCD+ individuals, and the diagnosis model will be established using the radiomics method. Finally, the follow-up visits will be conducted every 12 months and the primary outcome is the conversion to mild cognitive impairment or dementia. After a 4-year follow-up, we will extract factors associated with the conversion risk of SCD using Cox regression analysis. Results: At present, 141 SCD from China and 338 SCD from Germany have been recruited. Initial analysis showed significant differences in demographic information, neuropsychological tests, and regional brain atrophy in SCD compared with controls in both cohorts. Conclusion: This project may be of great value for future implications of SCD studies in different cultural backgrounds. Trial registration: ClinicalTrials.gov, NCT04696315. Registered 3 January 2021.
- Subjects :
- Cross-Cultural Comparison
congenital, hereditary, and neonatal diseases and abnormalities
epidemiology [Germany]
Neuropsychological Tests
pathology [Alzheimer Disease]
cross-cultural
Alzheimer Disease
hemic and lymphatic diseases
Germany
magnetic resonance imaging
Humans
Cognitive Dysfunction
ddc:610
cardiovascular diseases
Longitudinal Studies
Amyloid beta-Peptides
General Neuroscience
amyloid
General Medicine
Psychiatry and Mental health
Clinical Psychology
diagnosis [Cognitive Dysfunction]
radiomics
subjective cognitive decline
Geriatrics and Gerontology
Alzheimer’s disease
Subjects
Details
- ISSN :
- 18758908
- Volume :
- 87
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....765c79238ed74da57ecbfc642bfd24dd