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c-Jun mediates axotomy-induced dopamine neuron death in vivo
- Source :
- Proceedings of the National Academy of Sciences. 98:13385-13390
- Publication Year :
- 2001
- Publisher :
- Proceedings of the National Academy of Sciences, 2001.
-
Abstract
- Expression of the transcription factor c-Jun is induced in neurons of the central nervous system (CNS) in response to injury. Mechanical transection of the nigrostriatal pathway at the medial forebrain bundle (MFB) results in the delayed retrograde degeneration of the dopamine neurons in the substantia nigra pars compacta (SNc) and induces protracted expression and phosphorylation of c-Jun. However, the role of c-Jun after axotomy of CNS neurons is unclear. Here, we show that adenovirus-mediated expression of a dominant negative form of c-Jun (Ad.c-JunDN) inhibited axotomy-induced dopamine neuron death and attenuated phosphorylation of c-Jun in nigral neurons. Ad.c-JunDN also delayed the degeneration of dopaminergic nigral axons in the striatum after MFB axotomy. Taken together, these findings suggest that activation of c-Jun mediates the loss of dopamine neurons after axotomy injury.
- Subjects :
- Male
Cell Survival
Proto-Oncogene Proteins c-jun
Dopamine
medicine.medical_treatment
Nigrostriatal pathway
Apoptosis
Substantia nigra
Striatum
Biology
Serine
medicine
Animals
Phosphorylation
Rats, Wistar
Chromatography, High Pressure Liquid
Multidisciplinary
Pars compacta
Dopaminergic
Axotomy
Anatomy
Biological Sciences
Immunohistochemistry
Rats
medicine.anatomical_structure
nervous system
Neuron death
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....767431cfedaf93c6b998a63ab5e5ac4b