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Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 concentrations and prognosis of aneurysmal subarachnoid hemorrhage
- Source :
- Clinica Chimica Acta. 500:54-58
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Oxidized low-density lipoprotein (ox-LDL) and its receptor, lectin-like ox-LDL receptor-1 (LOX-1) are involved in the pathogenesis of atherosclerosis. Expression of LOX-1 was substantially raised in the basilar arterial wall of subarachnoid hemorrhage (SAH) rabbits. We ascertained the relationship between serum soluble LOX-1 concentrations and functional outcome after human aneurysmal SAH.We enrolled 94 aneurysmal SAH patients and 94 healthy controls. Serum soluble TOX-1 concentrations were quantified using commercial enzyme-linked immunosorbent assay kit. A poor outcome was defined as Glasgow outcome scale score of 1-3.Median values of serum soluble LOX-1 in stroke patients were significantly higher than those in controls (1.5 vs. 0.4 ng/ml, P 0.001). Thirty patients (31.9%) had a poor outcome at 6 months after stroke. Serum soluble LOX-1 was a strong predictor of poor outcome (OR 5.20, 95% CI 1.25-22.04). Serum soluble LOX-1 concentrations exhibited a significant discriminatory capability (area under curve 0.811, 95% confidence interval 0.717-0.884). The predictive powers of World Federation of Neurological Surgeons grade, Hunt-Hess grade, modified Fisher grade, and serum soluble LOX-1 concentrations were comparable (all P 0.05).Serum soluble LOX-1 appears to have the potential to become a promising prognostic predictor after human aneurysmal SAH.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Subarachnoid hemorrhage
Stroke patient
OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1
Clinical Biochemistry
Biochemistry
Gastroenterology
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
cardiovascular diseases
Receptor
biology
business.industry
Glasgow Outcome Scale
Biochemistry (medical)
Lectin
General Medicine
Middle Aged
Subarachnoid Hemorrhage
Prognosis
Scavenger Receptors, Class E
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
biology.protein
Female
business
Lipoprotein
Subjects
Details
- ISSN :
- 00098981
- Volume :
- 500
- Database :
- OpenAIRE
- Journal :
- Clinica Chimica Acta
- Accession number :
- edsair.doi.dedup.....7678b32775d4a3bede595455a98c4e8e