Diuretic Evaluation of Chlorazinal

The average weight loss after 48 hours in 14 ambulatory cardiac patients receiving chlorazinal was 1.6 lb., comparing favorably with the response to other oral diuretics. Determinations of blood urea nitrogen and creatinine levels and urinalyses in 29 patients receiving the drug indicated that it tends to increase blood urea and to increase cellular content and casts in the urine in certain patients; an exception was a patient with acute glomerulonephritis in whom the blood urea decreased.