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Complex polycyclic scaffolds by metathesis rearrangement of Himbert arene/allene cycloadducts
- Source :
- Organic letters. 14(21)
- Publication Year :
- 2012
-
Abstract
- The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.
- Subjects :
- chemistry.chemical_classification
Natural product
Cycloaddition Reaction
Molecular Structure
Alkene
Allene
Organic Chemistry
Alkenes
Metathesis
Biochemistry
Cycloaddition
chemistry.chemical_compound
chemistry
Cyclization
Intramolecular force
Rapid access
Organic chemistry
Polycyclic Compounds
Physical and Theoretical Chemistry
Heterocyclic Compounds, 3-Ring
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 14
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....76875e14e8c5ccc79aee154b4acfeb81