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Human methionine synthase A2756G polymorphism increases susceptibility to prostate cancer
- Source :
- Aging (Albany NY)
- Publication Year :
- 2018
- Publisher :
- Impact Journals, LLC, 2018.
-
Abstract
- Background/Aims: Previous results on the association between MTR gene A2756G polymorphism and PCa risk are inconclusive. Methods: We used odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) to evaluate the correlation between MTR A2756G polymorphism and risk of PCa in meta-analysis. Serum expression of MTR was detected by ELISA and in-silico tools were utilized to assess this variant. Results: Our study included 2,921 PCa patients and 3,095 control subjects. The results indicated that the MTR A2756G polymorphism is linked with an increased risk of PCa using three genetic models (G-allele vs. A-allele: OR = 1.16, 95%CI = 1.04 - 1.30; GA vs. AA: OR = 1.17, 95%CI = 1.02 - 1.33; GG+GA vs. AA: OR = 1.18, 95%CI = 1.04 - 1.34). Stratified analysis produced similar results. A significant association was also indicated in advanced PCa from the meta-analysis. Finally, our experiments showed evidence that serum MTR levels in PCa patients with AA genotypes were statistically higher than in those with GG/GA genotypes. Conclusions: Our present study suggests that the MTR A2756G polymorphism may contribute to the risk of developing PCa, particularly in Asian and hospital-based studies. Moreover, serum MTR might be utilized in diagnosis of PCa.
- Subjects :
- Male
0301 basic medicine
Aging
medicine.medical_specialty
Genotype
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Models, Biological
Polymorphism, Single Nucleotide
Gastroenterology
Gene Expression Regulation, Enzymologic
polymorphism
Correlation
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Internal medicine
Genetic model
Genetic variation
medicine
Humans
Computer Simulation
Genetic Predisposition to Disease
Methionine synthase
methionine synthase
Aged
Aged, 80 and over
biology
business.industry
Prostatic Neoplasms
Cell Biology
Odds ratio
Middle Aged
prostate cancer
medicine.disease
Confidence interval
030104 developmental biology
030220 oncology & carcinogenesis
genetic variation
biology.protein
ELISA
business
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....768e7efa028e68a6116d553122665243