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An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
- Source :
- Genome biology, vol 17, iss 1, Genome Biology, Genome Biology, 2016, 17 (1), pp.171. ⟨10.1186/s13059-016-1030-0⟩
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Background Epigenetic biomarkers of aging (the “epigenetic clock”) have the potential to address puzzling findings surrounding mortality rates and incidence of cardio-metabolic disease such as: (1) women consistently exhibiting lower mortality than men despite having higher levels of morbidity; (2) racial/ethnic groups having different mortality rates even after adjusting for socioeconomic differences; (3) the black/white mortality cross-over effect in late adulthood; and (4) Hispanics in the United States having a longer life expectancy than Caucasians despite having a higher burden of traditional cardio-metabolic risk factors. Results We analyzed blood, saliva, and brain samples from seven different racial/ethnic groups. We assessed the intrinsic epigenetic age acceleration of blood (independent of blood cell counts) and the extrinsic epigenetic aging rates of blood (dependent on blood cell counts and tracks the age of the immune system). In blood, Hispanics and Tsimane Amerindians have lower intrinsic but higher extrinsic epigenetic aging rates than Caucasians. African-Americans have lower extrinsic epigenetic aging rates than Caucasians and Hispanics but no differences were found for the intrinsic measure. Men have higher epigenetic aging rates than women in blood, saliva, and brain tissue. Conclusions Epigenetic aging rates are significantly associated with sex, race/ethnicity, and to a lesser extent with CHD risk factors, but not with incident CHD outcomes. These results may help elucidate lower than expected mortality rates observed in Hispanics, older African-Americans, and women. Electronic supplementary material The online version of this article (doi:10.1186/s13059-016-1030-0) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
0301 basic medicine
Aging
Epigenetic clock
Ethnic group
Coronary Disease
Disease
Cardiovascular
Epigenesis, Genetic
MESH: DNA Methylation
MESH: Risk Factors
Risk Factors
MESH: Aging
MESH: Epigenesis, Genetic
MESH: Hispanic or Latino
MESH: Aged
African Americans
Genetics
Sex Characteristics
Hispanic paradox
DNA methylation
Continental Population Groups
Mortality rate
Incidence (epidemiology)
Hispanic or Latino
Biological Sciences
3. Good health
Black/white mortality cross-over
Coronary heart disease
Heart Disease
Female
Hispanic Americans
MESH: Sex Characteristics
Sex characteristics
Race
Bioinformatics
MESH: Whites
European Continental Ancestry Group
Biology
White People
03 medical and health sciences
Genetic
Clinical Research
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Information and Computing Sciences
MESH: United States
Humans
Epigenetics
Heart Disease - Coronary Heart Disease
Aged
MESH: Humans
Prevention
Research
Racial Groups
Gender
MESH: Male
United States
Black or African American
MESH: Racial Groups
Good Health and Well Being
030104 developmental biology
MESH: African Americans
Life expectancy
MESH: Coronary Disease
MESH: Female
Environmental Sciences
Epigenesis
Demography
Subjects
Details
- ISSN :
- 1474760X and 14656906
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Genome Biology
- Accession number :
- edsair.doi.dedup.....769229f1f9122b07805c51c1dfe8bd26