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Variation of B cell subsets with age in healthy Malawians
- Source :
- PLoS ONE, Vol 16, Iss 7, p e0254320 (2021), PLoS ONE
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Although a number of previous studies have shown that different lymphocyte subsets, including B cells, vary with age, how different B cell subsets vary with age in Malawian population has not been shown before. We recruited Malawian participants of different ages and analyzed their venous blood samples for different B cell subsets. We found that both percentage and absolute counts of B cells varied with age peaking in the 7 to 12 months age group. Proportion of naïve B cells was highest in neonates and decreased with age whereas the percentage of memory B cells was lowest in neonates and increased with age. When we zeroed in on the age band within which the proportion of B cells was highest, both classical and activated memory B cells increased with age and the naïve followed the opposite trend. These results provide additional knowledge in our understanding of the dynamics of B cell subsets in individuals of a specific ethnicity as they age.
- Subjects :
- Male
B Cells
Physiology
White Blood Cells
Spectrum Analysis Techniques
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Lymphocytes
education.field_of_study
Multidisciplinary
Total Cell Counting
Venous blood
Flow Cytometry
Body Fluids
Blood
medicine.anatomical_structure
Spectrophotometry
030220 oncology & carcinogenesis
Medicine
Cytophotometry
Cellular Types
Anatomy
Research Article
Lymphocyte subsets
Immune Cells
Science
Immunology
Cell Enumeration Techniques
Naive B cell
Population
B-Lymphocyte Subsets
Biology
Research and Analysis Methods
03 medical and health sciences
medicine
Humans
Lymphocyte Count
Antibody-Producing Cells
education
B cell
Blood Cells
Infant
Biology and Life Sciences
Cell Biology
Memory B cells
Age Groups
People and Places
Population Groupings
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....76ac70bcb6d4137347e316c68e83547e