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HER-2, Notch, and Breast Cancer Stem Cells: Targeting an Axis of Evil
- Source :
- Clinical Cancer Research. 15:1845-1847
- Publication Year :
- 2009
- Publisher :
- American Association for Cancer Research (AACR), 2009.
-
Abstract
- Increasing evidence indicates that tumor-initiating (cancer stem) cells may contribute to treatment resistance and relapse, suggesting that improved clinical outcome will require effective targeting of this cell population. Recent studies suggest that the remarkable clinical efficacy of trastuzumab may relate to its ability to target cancer stem cell populations.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Receptor, ErbB-2
Cell
Population
Breast Neoplasms
Antibodies, Monoclonal, Humanized
Breast cancer
Trastuzumab
Cancer stem cell
Cell Line, Tumor
Internal medicine
medicine
Humans
Clinical efficacy
education
education.field_of_study
Receptors, Notch
business.industry
Antibodies, Monoclonal
Cancer
medicine.disease
medicine.anatomical_structure
Female
Stem cell
business
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 15573265 and 10780432
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Clinical Cancer Research
- Accession number :
- edsair.doi.dedup.....76c73c587dd42172728f5de58ae1a611