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Clinical and economic assessment of the therapy of acute kidney injury in sepsis with continuous combined methods of renal replacement therapy
- Source :
- Вестник анестезиологии и реаниматологии, Vol 18, Iss 5, Pp 7-20 (2021)
- Publication Year :
- 2021
- Publisher :
- NEW TERRA Publishing House, 2021.
-
Abstract
- Objective: complex assessment of clinical and economic effectiveness as well as saving of the state budget assets within the therapy of patients with sepsis/septic shock based on different technologies of blood purification.Methods. Evaluation of direct and indirect costs of the eight blood purifcation methods. The target population includes adult patients 18+ with septic acute kidney injury. The study was conducted in compliance with acting Standards on Clinical Economic Studies used in the Russian Federation.The study methods included evaluation of existing randomized clinical studies and trials with data from network meta-analyses and systematic reviews of the target technologies. The direct medical and indirect non-medical costs were calculated and analyzed in respect of cost-effectiveness and budget impact analyses.Results. Direct and indirect costs were calculated for the sorption devices oXiris (Baxter International Inc.), Toraymyxin (Toray Medical Co.), Alteco LPS Adsorber (Alteco Medical AB), Toxipak (POKARD NPF), Desepta.LPS (BIOTECH M NPP), CytoSorb (CytoSorbents Inc.), HA330 (Jafron Biomedical Co.), Desepta (BIOTECH M NPP) for two time-horizons: 1-year period and 5-years period with discounting. For both periods, the use of oXiris hemoflter results in the least economic burden for the state budget.Conclusion. The use of blood purifcation in septic patients therapy is associated with considerable direct and indirect fnancial expenses, the amount of which and consequential budget saving depend on the technology of blood purifcation applied. The actual tariff compensation policy evidently demands revising.
- Subjects :
- clinical economic study
medicine.medical_specialty
Target population
replacement renal therapy
Critical Care and Intensive Care Medicine
sepsis
Pharmacoeconomics
Indirect costs
blood purifcation
pharmacoeconomics
medicine
multiple organ dysfunction syndrome
health care economics and organizations
Adult patients
Septic shock
business.industry
RC86-88.9
Medical emergencies. Critical care. Intensive care. First aid
Budget impact
medicine.disease
cost effectiveness
Anesthesiology and Pain Medicine
Systematic review
acute kidney injury
Emergency medicine
Emergency Medicine
septic shock
Russian federation
business
Subjects
Details
- Language :
- Russian
- ISSN :
- 25418653 and 20785658
- Volume :
- 18
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Вестник анестезиологии и реаниматологии
- Accession number :
- edsair.doi.dedup.....76cae4a38237983741b652ed5e73194f