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Mucociliary transport using 99mTc-albumin colloid: a reliable screening test for primary ciliary dyskinesia
- Publication Year :
- 2005
- Publisher :
- BMJ Group, 2005.
-
Abstract
- Background: A study was undertaken to assess the reliability of the nasal mucociliary transport test using 99mTc-albumin colloid as a screening test for primary ciliary dyskinesia (PCD) and to compare it with the gold standard nasal biopsy for study of ciliary motility and ultrastructure. Methods: During a 4 year period both tests were performed in 55 children referred with persistent or recurrent respiratory tract infections. Their median age was 4 years (range 1 month to 15 years). Results: The nasal biopsy results were as follows: PCD, n = 8; secondary ciliary dyskinesia (SCD), n = 19; normal, n = 28. The mucociliary transport test was abnormal in 29 patients (all 8 with PCD, 7/19 with SCD, and 14/28 with a normal biopsy). The sensitivity of the mucociliary transport test to diagnose PCD was therefore 100% (8/8) (95% exact confidence limits 63.06 to 100.00); the specificity was only 55% (26/47) (40.95 to 69.89). The negative predictive value was 100% (26/26) (86.77 to 100.00) and the positive predictive value was 28% (8/29) (12.37 to 47.24). Conclusion: Mucociliary transport is a non-invasive screening test that can be performed even in infants. The sensitivity of the test is high but its specificity is low. A normal test result excludes PCD.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Pathology
Adolescent
Mucociliary clearance
Biopsy
Nose
Gastroenterology
Sensitivity and Specificity
Statistics, Nonparametric
Internal medicine
medicine
otorhinolaryngologic diseases
Humans
Child
Radionuclide Imaging
Technetium Tc 99m Aggregated Albumin
Primary ciliary dyskinesia
medicine.diagnostic_test
business.industry
Respiratory disease
Infant
Gold standard (test)
medicine.disease
medicine.anatomical_structure
Dyskinesia
Mucociliary Clearance
Child, Preschool
Ciliary Motility Disorders
Airway Biology
medicine.symptom
Radiopharmaceuticals
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....76dfa52bcb636ab5e9605ea56063ba63