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Perfusion Computed Tomography Findings of Autoimmune Pancreatitis
- Source :
- Pancreas. 40:1295-1301
- Publication Year :
- 2011
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2011.
-
Abstract
- Objectives The aim of this study was to clarify the pancreatic blood perfusion in patients with autoimmune pancreatitis (AIP) and the changes after steroid treatment. Methods Perfusion computed tomography was performed in 11 patients with AIP and 12 control subjects. Pancreatic volumetric blood flow (F(V)), volume of distribution (V(D)), and blood transit time τ were determined from a single-compartment kinetic model. Nine patients with AIP were reexamined by perfusion computed tomography after corticosteroid administration. Results The pancreatic F(V) values of the 11 patients with AIP (82.7/min) were significantly lower than those of control subjects (163.5/min, P = 0.0006). On the other hand, the pancreatic V(D) and τ values were not significantly different between AIP and normal. After steroid treatment, the F(V) values of 9 reexamined patients with AIP (76.2/min) were significantly elevated (109.8/min, P = 0.0391). However, the changes of the values after the treatment differed in degree among individuals. The values of 4 patients were dramatically elevated to greater than 100/min, whereas those of 4 other patients did not improve well. The value of the remaining patient whose initial F(V) value was normal (168.09/min) did not change after the treatment. Conclusions Pancreatic volumetric perfusion was attenuated in AIP patients. The perfusion was improved after the steroid treatment.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Autoimmune Diseases
Neovascularization
Endocrinology
Adrenal Cortex Hormones
Internal Medicine
medicine
Humans
Pancreas
Aged
Autoimmune pancreatitis
Aged, 80 and over
Volume of distribution
Neovascularization, Pathologic
Hepatology
medicine.diagnostic_test
business.industry
Blood flow
Middle Aged
medicine.disease
medicine.anatomical_structure
Pancreatitis
Regional Blood Flow
Immunoglobulin G
Corticosteroid
Female
Radiology
medicine.symptom
Tomography, X-Ray Computed
Nuclear medicine
business
Perfusion
Emission computed tomography
Subjects
Details
- ISSN :
- 08853177
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....76e0028bab342901523e94e49dd384bd