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High risk of congenital hypothyroidism in multiple pregnancies
- Source :
- 92(8) (2007): 3141–3147., info:cnr-pdr/source/autori:Olivieri A., Medda E., De Angelis S., Valensise H., De Felice M., Fazzini C., Cascino I., Cordeddu V., Sorcini M., Stazi M.A. and the Study Group for Congenital Hypothyroidism./titolo:High risk of congenital hypothyroidism in multiple pregnancies./doi:/rivista:/anno:2007/pagina_da:3141/pagina_a:3147/intervallo_pagine:3141–3147/volume:92(8)
- Publication Year :
- 2007
- Publisher :
- Endocrine Society / Maryland:8401 Connecticut Avenue, Suite 900:Chevy Chase, MD 20815:(301)941-0200, (301)941-0200, (301)941-0232, EMAIL: journals@endo-society.org, INTERNET: http://www.endo.society.org, Fax: (301)941-0259, 2007.
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Abstract
- CONTEXT: In Italy, the surveillance of congenital hypothyroidism (CH) is performed by the Italian National Registry of Infants with CH (INRICH). Up to now, about 3600 infants with CH are recorded in the INRICH, and a high number of twins are included. OBJECTIVE: Our objective was to estimate the risk of CH in multiple and single deliveries and to compare neonatal features of CH twins with twins from the general population. DESIGN: The Italian population of CH infants recorded in the INRICH from 1989-2000 was investigated. RESULTS: A more than 3-fold higher frequency of twins was found in the CH population than in the general population, and for the first time, it was possible to estimate the CH incidence in multiple (10.1 in 10,000) and single deliveries (3.2 in 10,000 live births). Significantly higher frequencies of in situ gland as well as lower TSH mean level at screening were found in twin than in singleton CH babies. The concordance rate for permanent CH was very low (4.3%) and due to only three concordant couples. However, a high recurrence risk for CH was estimated in siblings of affected babies recorded in the INRICH, including twins considered as siblings. CONCLUSIONS: The high CH incidence observed in twins is worthy of interest for the high number of induced pregnancies in Italy as well as in other Western countries. Moreover, the low concordance rate for CH among twins together with a high recurrence risk for the disease among siblings indicates that environmental risk factors may act as a trigger on a susceptible genetic background in the etiology of the disease
- Subjects :
- Adult
Male
Risk
Heterozygote
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Concordance
Birth weight
Clinical Biochemistry
Population
Thyroid Gland
Twins
Thyrotropin
Context (language use)
Biochemistry
Neonatal Screening
Endocrinology
Internal medicine
medicine
Birth Weight
Humans
Sex Ratio
education
Pregnancy
education.field_of_study
Singleton
business.industry
Incidence (epidemiology)
Homozygote
Biochemistry (medical)
Congenital Hypothyroidism
Female
Infant, Newborn
Italy
Linear Models
Pregnancy, Multiple
Thyroxine
Infant
Newborn
medicine.disease
CONGENITAL HYPOTHYROIDISM
Congenital hypothyroidism
Diabetes and Metabolism
pregnancy
business
Multiple
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- 92(8) (2007): 3141–3147., info:cnr-pdr/source/autori:Olivieri A., Medda E., De Angelis S., Valensise H., De Felice M., Fazzini C., Cascino I., Cordeddu V., Sorcini M., Stazi M.A. and the Study Group for Congenital Hypothyroidism./titolo:High risk of congenital hypothyroidism in multiple pregnancies./doi:/rivista:/anno:2007/pagina_da:3141/pagina_a:3147/intervallo_pagine:3141–3147/volume:92(8)
- Accession number :
- edsair.doi.dedup.....76e9f87856dce704bd328a55155c3d2d