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NT‐proBNP as a marker for atrial fibrillation and heart failure in four observational outpatient trials
- Source :
- ESC Heart Failure, ESC Heart Failure, Vol 9, Iss 1, Pp 100-109 (2022)
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- Aims Heart failure (HF) and atrial fibrillation (AF) frequently coexist and are both associated with increased levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP). It is known that AF impairs the diagnostic accuracy of NT‐proBNP for HF. The aim of the present study was to compare the diagnostic and predictive accuracy of NT‐proBNP for HF and AF in stable outpatients with cardiovascular risk factors. Methods and results Data were obtained from the DIAST‐CHF trial, a prospective cohort study that recruited individuals with cardiovascular risk factors and followed them up for 12 years. Data were validated in three independent population‐based cohorts using the same inclusion/exclusion criteria: LIFE‐Adult (n = 2869), SHIP (n = 2013), and SHIP‐TREND (n = 2408). Serum levels of NT‐proBNP were taken once at baseline. The DIAST‐CHF study enrolled 1727 study participants (47.7% female, mean age 66.9 ± 8.1 years). At baseline, patients without AF or HF (n = 1375) had a median NT‐proBNP of 94 pg/mL (interquartile range 51;181). In patients with AF (n = 93), NT‐proBNP amounted to 667 (215;1130) pg/mL. It was significantly higher than in the first group (P 50% [n = 38; 603 (175;1070) pg/mL] and those without HF (P = 1.0). Receiver‐operating characteristic curves of NT‐proBNP showed a similar area under the curve (AUC) for the detection of AF at baseline (0.84, 95% CI [0.79–0.88]) and for HF with EF 50% was significantly lower (0.61 [0.56–0.65]) than for AF (P = 0.001). During follow‐up, AF was newly diagnosed in 157 (9.1%) and HF in 141 (9.6%) study participants. NT‐proBNP was a better predictor of incident AF during the first 2 years (AUC: 0.79 [0.75–0.83]) than of newly diagnosed HF (0.59 [0.55–0.63]; P 50% is very limited.
- Subjects :
- Male
medicine.medical_specialty
medicine.drug_class
Population
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Interquartile range
Internal medicine
Natriuretic Peptide, Brain
Outpatients
medicine
Natriuretic peptide
Diseases of the circulatory (Cardiovascular) system
Humans
cardiovascular diseases
030212 general & internal medicine
Prospective Studies
Prospective cohort study
education
Aged
Heart Failure
education.field_of_study
business.industry
Area under the curve
Atrial fibrillation
Original Articles
Biomarker
Middle Aged
medicine.disease
Brain natriuretic peptide
Peptide Fragments
Population‐based cohort studies
Heart failure
RC666-701
Cardiology
Original Article
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 20555822
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- ESC Heart Failure
- Accession number :
- edsair.doi.dedup.....7705e2e3176ce234b0cee9bf6b39d60b