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Pseudogene-mediated DNA demethylation leads to oncogene activation

Authors :
Ying Li
Yanjing V. Liu
Zhiyuan Chen
Li Chai
Mahmoud A. Bassal
Leilei Chen
Henry Yang
Junyu Yang
Junsu Kwon
Chong Gao
Yvonne Tay
Adrianna I. Jones
Daniel G. Tenen
Annalisa Di Ruscio
Source :
Science Advances. 7
Publication Year :
2021
Publisher :
American Association for the Advancement of Science (AAAS), 2021.

Abstract

Pseudogenes, noncoding homologs of protein-coding genes, once considered nonfunctional evolutionary relics, have recently been linked to patient prognoses and cancer subtypes. Despite this potential clinical importance, only a handful of12,000 pseudogenes in humans have been characterized in cancers to date. Here, we describe a previously unrecognized role for pseudogenes as potent epigenetic regulators that can demethylate and activate oncogenes. We focused on

Details

ISSN :
23752548
Volume :
7
Database :
OpenAIRE
Journal :
Science Advances
Accession number :
edsair.doi.dedup.....772ba5b5b56bedd7125d17ee19eea619