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Fc-gamma-receptor IIIa polymorphism and gene expression profile do not predict the prognosis in diffuse large B-cell lymphoma treated with R-CHOP protocol
- Source :
- Pathology oncology research : POR. 18(1)
- Publication Year :
- 2011
-
Abstract
- The addition of rituximab to conventional chemotherapy has significantly improved the treatment outcome in diffuse large B-cell lymphoma. However, differences in treatment response and survival data can be observed independently from the International Prognostic Index scores. The current study evaluated the impact of Fc-gamma-receptor IIIa polymorphism and gene expression profile on the response of DLBCL patients to R-CHOP therapy as well as on their survival results. Fifty-one patients were involved, thirty-two females, nineteen males, their median age was 53.1 years. The FCGR3A polymorphism at the 158. amino acid position determined with PCR method showed the following results: VV: 12 cases (23.5%), VF: 29 cases (56.8%) and FF: 10 cases (19.6%), respectively. There was no significant difference between the treatment responses of the three groups. The event-free survival data were less favorable in the F-allele carriers than in V/V homozygous patients, but without any significancy, and the overall survival curves were almost the same. As for the gene expression profile, 20 patients’ biopsy specimens showed germinal center and 31 showed non-germinal center characteristics. Treatment results did not differ from each other in the two groups. Both the event-free and the overall survival data were more favorable in the GC group, however the differences were not significant. Our results contest the predictive value of Fc-gamma-receptor IIIa polymorphism and gene expression profile in diffuse large B-cell lymphoma.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Pathology
Adolescent
Klinikai orvostudományok
Gastroenterology
Polymorphism, Single Nucleotide
Pathology and Forensic Medicine
Antibodies, Monoclonal, Murine-Derived
International Prognostic Index
Internal medicine
Biopsy
Gene expression
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Cyclophosphamide
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Gene Expression Profiling
Receptors, IgG
FCGR3A
Germinal center
General Medicine
Orvostudományok
Middle Aged
medicine.disease
Prognosis
Lymphoma
Survival Rate
Treatment Outcome
Oncology
Doxorubicin
Vincristine
Prednisone
Rituximab
Female
Lymphoma, Large B-Cell, Diffuse
business
Diffuse large B-cell lymphoma
medicine.drug
Subjects
Details
- ISSN :
- 15322807
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pathology oncology research : POR
- Accession number :
- edsair.doi.dedup.....772de73c1dc5deb2efc36e6669ebc8eb