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Imaging and clinical correlates with regorafenib in metastatic colorectal cancer
- Source :
- Cancer treatment reviews, 86
- Publication Year :
- 2020
-
Abstract
- In colorectal cancer (CRC), imaging is important in determining tumor stage, selecting treatment strategies, and in assessing response to therapy. However, some challenges remain with established imaging techniques, such as computed tomography, and with some commonly used response criteria, such as Response Evaluation Criteria in Solid Tumors, which measures change in size of several target lesions instead of change in tumor morphology or metabolic function. In addition, these assessments are not typically conducted until after 8 weeks of treatment, meaning that potential non-responders are often not identified in a timely manner. Regorafenib, an oral tyrosine kinase inhibitor indicated for the treatment of metastatic CRC, blocks the activity of several protein kinases involved in angiogenesis, oncogenesis, metastasis, and tumor immunity. Timely differentiation of regorafenib responders from non-responders using appropriate imaging techniques that recognize not only changes in tumor size but also changes in tumor density or vasculature, may reduce unnecessary drug-related toxicity in patients who are unlikely to respond to treatment. This review discusses the latest developments in computed tomography, magnetic resonance imaging, and positron emission tomography tumor imaging modalities, and how these aid in identifying patients with metastatic CRC who are responders or non-responders to regorafenib treatment.<br />SCOPUS: re.j<br />info:eu-repo/semantics/published
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Positron emission tomography
Colorectal cancer
medicine.drug_class
Angiogenesis
Pyridines
Tyrosine-kinase inhibitor
Metastasis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Magnetic resonance imaging
Internal medicine
Regorafenib
medicine
Humans
Radiology, Nuclear Medicine and imaging
Neoplasm Metastasis
Imagerie médicale, radiologie, tomographie
Computed tomography
Protein Kinase Inhibitors
Randomized Controlled Trials as Topic
medicine.diagnostic_test
Neovascularization, Pathologic
business.industry
Metastatic colorectal cancer
Phenylurea Compounds
General Medicine
medicine.disease
Magnetic Resonance Imaging
Cancérologie
030104 developmental biology
chemistry
Response Evaluation Criteria in Solid Tumors
030220 oncology & carcinogenesis
Positron-Emission Tomography
business
Colorectal Neoplasms
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 15321967
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Cancer treatment reviews
- Accession number :
- edsair.doi.dedup.....773c8a5affcca202ca5b088250bee6fe