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Role of 68Ga-PSMA-PET/CT for the detection of primary prostate cancer prior to biopsy: a prospective study
- Source :
- Central European Journal of Urology
- Publication Year :
- 2021
- Publisher :
- Polish Urological Association, 2021.
-
Abstract
- Introduction Prostate-specific membrane antigen (PSMA) positron emission tomography/ computed tomography (PET-CT) is widely used as a staging tool for patients with prostate cancer (PCa). The objective of the study is to assess the diagnostic accuracy of 68Ga-PSMA-PET/CT for PCa, which may help us avoid unnecessary biopsies in patients with intermediate prostate-specific antigen (PSA) levels. Material and methods In this prospective study, 81 patients suspected of PCa, with either raised PSA between 4–20 ng/ml or abnormal digital rectal examination (DRE) findings were included. 68Ga-PSMA-PET/CT was performed for all patients followed by transrectal ultrasound (TRUS) guided prostate biopsy. SUVmax (maximum standardized uptake value) was measured and correlated with biopsy results. Results Out of 81 patients, 31 (38.3%) patients were found to have malignancy on biopsy. Median SUVmax of biopsy positive patients was 10.4 (IQR 6.5–16.1) and biopsy negative patients (n=50) was 3.5 (IQR 1–4.9), (p
- Subjects :
- Original Paper
medicine.medical_specialty
PET-CT
Prostate biopsy
medicine.diagnostic_test
business.industry
positron emission tomography/computed tomography
Standardized uptake value
General Medicine
Rectal examination
prostate cancer
urologic and male genital diseases
medicine.disease
Prostate cancer
Positron emission tomography
Biopsy
medicine
biopsy
Radiology
business
Prospective cohort study
68Ga-PSMA ligand
Subjects
Details
- ISSN :
- 20804873
- Database :
- OpenAIRE
- Journal :
- Central European Journal of Urology
- Accession number :
- edsair.doi.dedup.....773da7da0f53b9edf4cd3f083daf9902
- Full Text :
- https://doi.org/10.5173/ceju.2021.0084.r3