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Role of 68Ga-PSMA-PET/CT for the detection of primary prostate cancer prior to biopsy: a prospective study

Authors :
Umesh Sharma
Hemant Goel
Harsh Jain
Rajeev Sood
Mohammad Shazib Faridi
Source :
Central European Journal of Urology
Publication Year :
2021
Publisher :
Polish Urological Association, 2021.

Abstract

Introduction Prostate-specific membrane antigen (PSMA) positron emission tomography/ computed tomography (PET-CT) is widely used as a staging tool for patients with prostate cancer (PCa). The objective of the study is to assess the diagnostic accuracy of 68Ga-PSMA-PET/CT for PCa, which may help us avoid unnecessary biopsies in patients with intermediate prostate-specific antigen (PSA) levels. Material and methods In this prospective study, 81 patients suspected of PCa, with either raised PSA between 4–20 ng/ml or abnormal digital rectal examination (DRE) findings were included. 68Ga-PSMA-PET/CT was performed for all patients followed by transrectal ultrasound (TRUS) guided prostate biopsy. SUVmax (maximum standardized uptake value) was measured and correlated with biopsy results. Results Out of 81 patients, 31 (38.3%) patients were found to have malignancy on biopsy. Median SUVmax of biopsy positive patients was 10.4 (IQR 6.5–16.1) and biopsy negative patients (n=50) was 3.5 (IQR 1–4.9), (p

Details

ISSN :
20804873
Database :
OpenAIRE
Journal :
Central European Journal of Urology
Accession number :
edsair.doi.dedup.....773da7da0f53b9edf4cd3f083daf9902
Full Text :
https://doi.org/10.5173/ceju.2021.0084.r3