Regulating Stem Cell Secretome Using Injectable Hydrogels with In situ Network Formation

A family of Shear-thinning Hydrogels for Injectable Encapsulation and Long-term Delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. We demonstrate that SHIELD with an intermediate stiffness (200 – 400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells (hASCs).