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Glassy cell carcinoma of the cervix: a systematic review and meta-analysis
- Source :
- Gynecologic oncology. 133(2)
- Publication Year :
- 2013
-
Abstract
- Objective The purpose of this study is to summarize the data on the incidence, clinical behavior and overall survival of patients with glassy cell cervical carcinoma (GCCC). Methods Twenty-four case series and fifteen case reports identified by searching PubMed database qualified for inclusion in this study. The published cases were combined with data from a retrospective chart review of patients with GCCC in two major teaching hospitals in Brooklyn, NY. Results A total of 292 cases were collected through our literature and chart review. Median age at diagnosis was 45 years old (range 12-87 years of age). GCCC incidence ranges from 0.2 to 9.3% of all cervical cancers and 2 to 30.2% of cervical adenocarcinomas. The stage distribution is similar to squamous cell carcinoma with 79% of the patients being diagnosed with Stage I or II disease. Most common sites of recurrence for Stage I patients are the vagina and pelvis. In Stage II patients locoregional and distant metastases are equally common. Recurrence rate was higher among patients treated only with surgery (32.7%), as compared to patients treated with surgery followed by radiation (11%) or patients treated with radiation only (10%). Median overall survival (OS) was 25 months (95% CI 8.4-41.6). Overall 5-year survival for all stages is lower when compared to all cervical cancers (54.8% vs 75%). There was no interaction between race and OS (p=0.66). Conclusion GCCC is a rare histologic type of cervical cancer that presents at a younger age, is associated with high risk for distant failure and carries worse prognosis as compared to the squamous cell type. Radiation therapy is associated with decreased risk of recurrence.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Uterine Cervical Neoplasms
Antineoplastic Agents
Hysterectomy
Carcinoma, Adenosquamous
Young Adult
Internal medicine
medicine
Humans
Young adult
Stage (cooking)
Child
Cervix
Aged
Neoplasm Staging
Retrospective Studies
Cervical cancer
Aged, 80 and over
Radiotherapy
business.industry
Incidence (epidemiology)
Obstetrics and Gynecology
Retrospective cohort study
Middle Aged
medicine.disease
Prognosis
Combined Modality Therapy
Surgery
Radiation therapy
medicine.anatomical_structure
Oncology
Female
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 10956859
- Volume :
- 133
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Gynecologic oncology
- Accession number :
- edsair.doi.dedup.....7773a9b1127d63b5bb952780c7b89439