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Lipoprotein(a) and Risk of Ischemic Stroke in the REGARDS Study
- Source :
- Arteriosclerosis, Thrombosis, and Vascular Biology. 39:810-818
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Objective— Increased Lp(a) [lipoprotein(a)] is associated with coronary heart disease risk, but links with stroke are less consistent. Blacks have higher Lp(a) levels and stroke incidence than whites but have been underrepresented in studies. We hypothesized that Lp(a) is a risk factor for ischemic stroke and that risk differs by race. Approach and Results— REGARDS (Reasons for Geographic and Racial Differences in Stroke) recruited 30 239 black and white US adults aged ≥45 in 2003–2007 to study regional and racial differences in stroke mortality. We measured baseline Lp(a) by immunonephelometric assay in 572 cases of incident ischemic stroke and a 967-person cohort random sample. The hazard ratio of stroke by baseline Lp(a) was calculated using Cox proportional hazards models, stratified by race. Lp(a) was modeled in sex- and race-specific quartiles, given known differences in distributions by race and sex. Interactions were tested by including interaction terms in the proportional hazards models, with P P interaction=0.12. Lp(a) was lower in men than women, but associations with stroke in men and women were similar. Conclusions— We confirm that Lp(a) is a risk factor for ischemic stroke. Further research is needed to confirm the role of racial differences of the Lp(a) risk multiplier in ischemic stroke.
- Subjects :
- Male
Risk
medicine.medical_specialty
Black People
030204 cardiovascular system & hematology
White People
Article
Brain Ischemia
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Geography, Medical
Stroke
Aged
Proportional Hazards Models
biology
business.industry
Proportional hazards model
Incidence (epidemiology)
Models, Cardiovascular
Lipoprotein(a)
Middle Aged
medicine.disease
Lipids
United States
Coronary heart disease
Ischemic stroke
biology.protein
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Stroke incidence
030217 neurology & neurosurgery
Follow-Up Studies
Program Evaluation
Lipoprotein
Subjects
Details
- ISSN :
- 15244636 and 10795642
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Accession number :
- edsair.doi.dedup.....777700aa499b7fa865db6d41005b720e