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Effect of temporal sampling protocols on myocardial blood flow measurements using Rubidium-82 PET
- Source :
- Journal of nuclear cardiology, 29, 1729-1741. Springer
- Publication Year :
- 2022
-
Abstract
- Background A variety of temporal sampling protocols is used worldwide to measure myocardial blood flow (MBF). Both the length and number of time frames in these protocols may alter MBF and myocardial flow reserve (MFR) measurements. We aimed to assess the effect of different clinically used temporal sampling protocols on MBF and MFR quantification in Rubidium-82 (Rb-82) PET imaging. Methods We retrospectively included 20 patients referred for myocardial perfusion imaging using Rb-82 PET. A literature search was performed to identify appropriate sampling protocols. PET data were reconstructed using 14 selected temporal sampling protocols with time frames of 5-10 seconds in the first-pass phase and 30-120 seconds in the tissue phase. Rest and stress MBF and MFR were calculated for all protocols and compared to the reference protocol with 26 time frames. Results MBF measurements differed (P ≤ 0.003) in six (43%) protocols in comparison to the reference protocol, with mean absolute relative differences up to 16% (range 5%-31%). Statistically significant differences were most frequently found for protocols with tissue phase time frames P ≥ 0.11) for any of the protocols. Conclusions Various temporal sampling protocols result in different MBF values using Rb-82 PET. MFR measurements were more robust to different temporal sampling protocols.
- Subjects :
- UT-Hybrid-D
Coronary Artery Disease
Regadenoson
Myocardial blood flow
Myocardial perfusion imaging
Coronary Circulation
Temporal sampling
medicine
Humans
Radiology, Nuclear Medicine and imaging
Retrospective Studies
82rb
Protocol (science)
medicine.diagnostic_test
business.industry
Phase time
Myocardial Perfusion Imaging
Sampling (statistics)
Blood flow
Pet imaging
PET myocardial perfusion imaging
Rubidium-82
Positron-Emission Tomography
Cardiology and Cardiovascular Medicine
business
Rubidium Radioisotopes
Biomedical engineering
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 10713581
- Database :
- OpenAIRE
- Journal :
- Journal of nuclear cardiology, 29, 1729-1741. Springer
- Accession number :
- edsair.doi.dedup.....779ed1443b0ba4e5ccc9c0a8ab476660