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Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans
- Source :
- Journal of Biological Chemistry. 290:29231-29239
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Increasing evidence indicates that immune responses to microbial infections may contribute to neurodegenerative diseases. Here, we show that Pseudomonas aeruginosa infection of Caenorhabditis elegans causes a number of neural changes that are hallmarks of neurodegeneration. Using an unbiased genetic screen to identify genes involved in the control of P. aeruginosa-induced neurodegeneration, we identified mes-1, which encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germ line. We showed that sterile but not fertile mes-1 animals were resistant to neurodegeneration induced by P. aeruginosa infection. Similar results were observed using animals carrying a mutation in the maternal effect gene pgl-1, which is required for postembryonic germ line development, and the germ line-deficient strains glp-1 and glp-4. Additional studies indicated that the FOXO transcription factor DAF-16 is required for resistance to P. aeruginosa-induced neurodegeneration in germ line-deficient strains. Thus, our results demonstrate that P. aeruginosa infection results in neurodegeneration phenotypes in C. elegans that are controlled by the germ line in a cell-nonautonomous manner.
- Subjects :
- Immunology
Green Fluorescent Proteins
Biology
medicine.disease_cause
Biochemistry
Osmotic Pressure
RNA interference
medicine
Animals
Pseudomonas Infections
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Molecular Biology
Gene
Genetics
Mutation
Chemotaxis
Neurodegeneration
Neurodegenerative Diseases
Cell Biology
biochemical phenomena, metabolism, and nutrition
medicine.disease
biology.organism_classification
Phenotype
Immunity, Innate
Disease Models, Animal
Host-Pathogen Interactions
Pseudomonas aeruginosa
RNA Interference
Germ line development
Genetic screen
Subjects
Details
- ISSN :
- 00219258
- Volume :
- 290
- Database :
- OpenAIRE
- Journal :
- Journal of Biological Chemistry
- Accession number :
- edsair.doi.dedup.....77a11aff55afb005d1014b89eab2ad96