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Neuropeptide Y as a risk factor for cardiorenal disease and cognitive dysfunction in chronic kidney disease: translational opportunities and challenges
- Source :
- Nephrology Dialysis Transplantation
- Publication Year :
- 2021
-
Abstract
- Neuropeptide Y (NPY) is a 36-amino-acid peptide member of a family also including peptide YY and pancreatic polypeptide, which are all ligands to Gi/Go coupled receptors. NPY regulates several fundamental biologic functions including appetite/satiety, sex and reproduction, learning and memory, cardiovascular and renal function and immune functions. The mesenteric circulation is a major source of NPY in the blood in man and this peptide is considered a key regulator of gut-brain cross talk. A progressive increase in circulating NPY accompanies the progression of chronic kidney disease (CKD) toward kidney failure and NPY robustly predicts cardiovascular events in this population. Furthermore, NPY is suspected as a possible player in accelerated cognitive function decline and dementia in patients with CKD and in dialysis patients. In theory, interfering with the NPY system has relevant potential for the treatment of diverse diseases from cardiovascular and renal diseases to diseases of the central nervous system. Pharmaceutical formulations for effective drug delivery and cost, as well as the complexity of diseases potentially addressable by NPY/NPY antagonists, have been a problem until now. This in part explains the slow progress of knowledge about the NPY system in the clinical arena. There is now renewed research interest in the NPY system in psychopharmacology and in pharmacology in general and new studies and a new breed of clinical trials may eventually bring the expected benefits in human health with drugs interfering with this system. Funding Agencies|COST Action CA19127-Cognitive Decline in Nephro-Neurology: European Cooperative Target (CONNECT)
- Subjects :
- dialysi
Hypertension, Renal
hypertension
medicine.medical_treatment
Population
Review
Bioinformatics
Renal Dialysis
Risk Factors
Renin–angiotensin system
mental disorders
medicine
CKD
Dementia
Humans
Cognitive Dysfunction
Neuropeptide Y
Renal Insufficiency, Chronic
education
Receptor
AcademicSubjects/MED00340
renin–angiotensin system
Dialysis
Rheumatology and Autoimmunity
Reumatologi och inflammation
Transplantation
education.field_of_study
Kidney
business.industry
cardiovascular
Neuropeptide Y receptor
medicine.disease
humanities
Receptors, Neuropeptide Y
medicine.anatomical_structure
Nephrology
Peptide YY
dialysis
business
renin-angiotensin system
Subjects
Details
- ISSN :
- 14602385
- Volume :
- 37
- Issue :
- Suppl 2
- Database :
- OpenAIRE
- Journal :
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- Accession number :
- edsair.doi.dedup.....77a135900c410479b768b5f6fb0695de