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Expression and clinical value of CD105 in renal cell carcinoma based on data mining in The Cancer Genome Atlas
- Source :
- Experimental and Therapeutic Medicine
- Publication Year :
- 2019
- Publisher :
- Spandidos Publications, 2019.
-
Abstract
- The objective of the present study was to assess the expression of CD105 and its association with overall survival in three subtypes of renal cell carcinoma (RCC), namely clear cell (cc)RCC, papillary (p)RCC and chromophobe (ch)RCC. Data regarding the transcriptome and copy number of genes in RCC tumor samples and survival were obtained from The Cancer Genome Atlas. Bioinformatics analysis revealed that CD105 is overexpressed in ccRCC tumor tissue vs. normal renal tissue, and a higher CD105 copy number in ccRCC tissues was significantly associated with longer patient survival. The effect of the mRNA expression of CD105 in all three types of RCC and the copy number in pRCC and chRCC on patient survival was insignificant, but certain trends were observed. In addition, CD105 mRNA expression was associated with the metastasis and tumor stage, as well as pathological stage in ccRCC and pRCC. Pathway enrichment analysis revealed that CD105 may, through translation initiation of associated genes, promote RCC progression. The results of the present study suggest that in RCC tumors, the association of CD105 with different stages is complex. To evaluate the role of CD105 in RCC, its function should be assessed in addition to its expression. The exact influence of CD105 mRNA expression and copy number in RCC tumors on patient survival and the underlying mechanisms require further elucidation.
- Subjects :
- 0301 basic medicine
renal cell carcinoma
Cancer Research
The Cancer Genome Atlas
Chromophobe cell
Biology
urologic and male genital diseases
survival
Metastasis
Transcriptome
03 medical and health sciences
0302 clinical medicine
Immunology and Microbiology (miscellaneous)
Renal cell carcinoma
medicine
neoplasms
Oncogene
Articles
General Medicine
Endoglin
Cell cycle
medicine.disease
female genital diseases and pregnancy complications
CD105
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
clinical value
Clear cell
Subjects
Details
- ISSN :
- 17921015 and 17920981
- Database :
- OpenAIRE
- Journal :
- Experimental and Therapeutic Medicine
- Accession number :
- edsair.doi.dedup.....77a27b72a7d6554ba342725f267e8fa8