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Regulatory CD4+CD25+ T lymphocytes in peripheral blood from patients with atopic asthma
- Source :
- Clinical Immunology. 113:172-178
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- The aim of this study was to analyze whether regulatory CD4+CD25+ T lymphocytes exist and function normally in patients with atopic asthma. Our data showed that a significant increase in CD4+CD25+ cell numbers was seen in atopic asthmatics during acute exacerbation, but not in those stable asthmatics, atopic nonasthmatics, and normal subjects. The mean inhibition values of the proliferation response of CD4+CD25β cells by CD4+CD25+ cells from normal controls and asthmatics were almost the same. There was no difference in inhibitory effects on both Th1 and Th2 cytokine production of CD4+CD25β cells by CD4+CD25+ cells in the two groups. These data demonstrated that although CD4+CD25+ cells increase in atopic asthma during exacerbation, these regulatory T cells appear to function normally with regard to suppression of T-cell proliferation as well as Th1βTh2 cytokine production.
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Hypersensitivity, Immediate
Male
Allergy
Exacerbation
medicine.medical_treatment
Immunology
chemical and pharmacologic phenomena
Lymphocyte Activation
Pathogenesis
Atopy
T-Lymphocyte Subsets
Humans
Immunology and Allergy
Medicine
IL-2 receptor
Asthma
business.industry
Receptors, Interleukin-2
hemic and immune systems
T lymphocyte
medicine.disease
body regions
Cytokine
Cytokines
Female
business
Subjects
Details
- ISSN :
- 15216616
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Clinical Immunology
- Accession number :
- edsair.doi.dedup.....77a74e593c66e3e4ae581d5840ec0240