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Fingerprint Stimulated Raman Scattering Imaging Reveals Retinoid Coupling Lipid Metabolism and Survival
- Source :
- Chemphyschem
- Publication Year :
- 2018
-
Abstract
- Retinoids play critical roles in development, immunity and lipid metabolism, and their deficiency leads to various human disorders. Yet, tools for sensing retinoids in vivo are lacking, which limits the understanding of retinoid distribution, dynamics and functions in living organisms. Here, using hyperspectral stimulated Raman scattering microscopy, we discover a previously unknown cytoplasmic store of retinoids in Caenorahbditis elegans. Following the temporal dynamics of retinoids, we reveal that their levels are positively correlated with fat storage, and their supplementation slows down fat loss during dauer starvation. We also discover that retinoids promote fat unsaturation in response to high-glucose stress, and improve organism survival. Together, our studies report a new method for tracking the spatiotemporal dynamics of retinoids in living organisms, and suggest the crucial roles of retinoids in maintaining metabolic homeostasis and enhancing organism fitness upon developmental and dietary stresses.
- Subjects :
- 0301 basic medicine
Cytoplasm
medicine.drug_class
Longevity
Spectrum Analysis, Raman
Article
03 medical and health sciences
Retinoids
0302 clinical medicine
In vivo
medicine
Animals
Retinoid
Physical and Theoretical Chemistry
Caenorhabditis elegans
Organism
Microscopy
Stimulated Raman Scattering Microscopy
Chemistry
Lipid metabolism
Lipid Metabolism
Atomic and Molecular Physics, and Optics
Cell biology
Coupling (electronics)
030104 developmental biology
Lysosomes
Fat loss
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14397641
- Volume :
- 19
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Chemphyschem : a European journal of chemical physics and physical chemistry
- Accession number :
- edsair.doi.dedup.....77e0f89cf15c787e7e62bf6b1fae1d1b