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Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
- Source :
- Journal of Lipid Research, Vol 50, Iss, Pp S63-S68 (2009)
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- The human genome expresses nine patatin-like phospholipase domain containing proteins (PNPLA1–9). Members of this family share a protein domain discovered initially in patatin, the most abundant protein of the potato tuber. Patatin is a lipid hydrolase with an unusual folding topology that differs from classical lipases. Mammalian PNPLAs include lipid hydrolases with specificities for diverse substrates such as triacylglycerols, phospholipids, and retinol esters. Analysis of induced mutant mouse models and the clinical phenotype of patients with mutations revealed important insights into the physiological role of several members of the PNPLA family. This review aims to summarize current knowledge of PNPLA proteins and to document their emerging importance in lipid and energy homeostasis.
- Subjects :
- Keratinocytes
Lipolysis
Mutant
QD415-436
Phospholipase
Biology
Biochemistry
Energy homeostasis
GS2-like
ATGL
Endocrinology
Hydrolase
Animals
Humans
Adiponutrin
education
Triglycerides
Biological Phenomena
Mammals
Genetics
education.field_of_study
PNPLA
food and beverages
Lipase
Cell Biology
NTE
Patatin-like phospholipase
adiponutrin
Enzymology
GS2
lipids (amino acids, peptides, and proteins)
Human genome
Patatin
Subjects
Details
- ISSN :
- 00222275
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Journal of Lipid Research
- Accession number :
- edsair.doi.dedup.....77e773c40cd320431d8e9b106004fff8