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Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor γ
- Source :
- Prostaglandins & Other Lipid Mediators. 93:126-133
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Cyclic phosphatidic acid (cPA), a structural analog of lysophosphatidic acid (LPA), is one of the simplest phospholipids found in every cell type. cPA is a specific, high-affinity antagonist of peroxisome proliferator-activated receptor gamma (PPARγ); however, the molecular mechanism by which cPA inhibits cellular proliferation remains to be clarified. In this study, we found that inhibition of PPARγ prevents proliferation of human colon cancer HT-29 cells. cPA suppressed cell growth, and this effect was reversed by the addition of a PPARγ agonist. These results indicate that the physiological effects of cPA are partly due to PPARγ inhibition. Our results identify PPARγ as a molecular mediator of cPA activity in HT-29 cells, and suggest that cPA and the PPARγ pathway might be therapeutic targets in the treatment of colon cancer.
- Subjects :
- medicine.medical_specialty
Cell type
Cell Survival
Physiology
Phosphatidic Acids
Peroxisome proliferator-activated receptor
Biology
Biochemistry
Heterocyclic Compounds, 1-Ring
chemistry.chemical_compound
Cell Line, Tumor
Internal medicine
Lysophosphatidic acid
medicine
Humans
heterocyclic compounds
Receptor
Cell Proliferation
Pharmacology
chemistry.chemical_classification
Cell growth
DNA
Cell Biology
Phosphatidic acid
Peroxisome
PPAR gamma
Endocrinology
chemistry
Nuclear receptor
Colonic Neoplasms
cardiovascular system
Cancer research
Lysophospholipids
HT29 Cells
Subjects
Details
- ISSN :
- 10988823
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- Prostaglandins & Other Lipid Mediators
- Accession number :
- edsair.doi.dedup.....77f0f6c9377d0c894f3137203daacd8b