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Obstructive Sleep Apnea and Cardiovascular Disease - A New Target for Treatment
- Source :
- Current Pharmaceutical Design. 21:3496-3504
- Publication Year :
- 2015
- Publisher :
- Bentham Science Publishers Ltd., 2015.
-
Abstract
- Obstructive sleep apnea (OSA) is characterized by recurrent episodes of partial (hypopnea) or complete interruption (apnea) in breathing during sleep due to airway collapse in the oral or pharyngeal region. Prospective studies have established the adverse cardiovascular consequences of OSA, including an increased risk for developing hypertension, coronary artery disease, stroke, and heart failure. However, more studies are needed to better assess the impact of OSA, and possible benefit of treatment with continuous positive airway pressure (CPAP) on cardiovascular mortality. The leading pathophysiological mechanisms involved in the changes triggered by OSA include intermittent hypoxemia and re-oxygenation, arousals and changes in intrathoracic pressure. Hypertension is strongly related with activation of the sympathetic nervous system, stimulation of the renin-angiotensin-aldosterone system and endothelial dysfunction. OSA should be suspected in hypertensive individuals, particularly in patients with resistant hypertension. CPAP treatment reduces blood pressure, and its effects are more pronounced in patients with high baseline blood pressure and elevated treatment compliance. At present, no clear evidence supports CPAP treatment for primary or secondary cardiovascular disease prevention.
- Subjects :
- medicine.medical_specialty
Sleep Apnea
medicine.medical_treatment
Heart failure
Hypoxemia
Risk Factors
Internal medicine
Drug Discovery
Animals
Humans
Medicine
Endothelial dysfunction
Continuous positive airway pressure
Pharmacology
Sleep Apnea, Obstructive
Continuous Positive Airway Pressure
Obstructive
business.industry
Apnea
Sleep apnea
Cardiovascular diseases
Coronary heart disease
Hypertension
Obstructive sleep apnea
Stroke
Cardiovascular Diseases
Patient Compliance
Sleep
medicine.disease
nervous system diseases
respiratory tract diseases
Blood pressure
Anesthesia
Cardiology
Cardiovascular diseases, coronary heart disease, endothelial dysfunction, heart failure, hypertension, obstructive sleep apnea, stroke
medicine.symptom
business
Hypopnea
Subjects
Details
- ISSN :
- 13816128
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Current Pharmaceutical Design
- Accession number :
- edsair.doi.dedup.....77f359808979c9dd774d20024f8a547d