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Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control
- Publication Year :
- 2017
- Publisher :
- American Thoracic Society, 2017.
-
Abstract
- Maintaining optimal symptom control remains the primary objective of asthma treatment. Better understanding of the biologic underpinnings of asthma control may lead to the development of improved clinical and pharmaceutical approaches.To identify molecular pathways and interrelated genes whose differential expression was associated with asthma control.We performed gene set enrichment analyses of asthma control in 1,170 adults with asthma, each with gene expression data derived from either whole blood (WB) or unstimulated CD4In the WB discovery cohort, we found significant overrepresentation of genes associated with asthma control in 1,106 gene sets from the Molecular Signatures Database (false discovery rate,5%). Of these, 583 (53%) replicated in at least one replication cohort (false discovery rate,25%). Suboptimal control was associated with signatures of eosinophilic and granulocytic inflammatory signals, whereas optimal control signatures were enriched for immature lymphocytic patterns. These signatures included two related biologic processes related to activation by TREM-1 (triggering receptor expressed on myeloid cells 1) and lipopolysaccharide.Together, these results demonstrate the existence of specific, reproducible transcriptomic components in blood that vary with degree of asthma control and implicate a novel biologic target (TREM-1).
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Male
0301 basic medicine
Pulmonary and Respiratory Medicine
Exacerbation
Critical Care and Intensive Care Medicine
Transcriptome
Young Adult
03 medical and health sciences
0302 clinical medicine
immune system diseases
medicine
Humans
Young adult
Precision Medicine
Asthma
Whole blood
Regulation of gene expression
business.industry
Gene Expression Profiling
Editorials
Original Articles
medicine.disease
respiratory tract diseases
Gene expression profiling
030104 developmental biology
Gene Expression Regulation
030228 respiratory system
Cohort
Immunology
Female
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....77f67f19dbbe4ce0b0398de8c586521a