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Therapy-Related Acute Megakaryoblastic Leukemia in a Lung Cancer Patient
- Source :
- Annals of Laboratory Medicine
- Publication Year :
- 2014
- Publisher :
- Annals of Laboratory Medicine, 2014.
-
Abstract
- Therapy-related AML (t-AML) is one of the newly expanded disease entities in the 2008 WHO classification, accounting for 10-20% of all cases of AML, and its incidence is increasing worldwide because of improved survival rates following treatment for other primary cancers [1, 2]. Acute megakaryoblastic leukemia (AMKL) (M7) is the least common of the t-AML French-American-British (FAB) subtypes, and only two such cases have been reported to date [3, 4], neither of which was in Korea. AMKL accounts for about 7-10% of childhood AML cases (frequently associated with Down syndrome), but only about 1% of adult AML cases [5]. Here, we describe a rare case of therapy-related acute megakaryoblastic leukemia (t-AMKL) with chromosome 5 and 7 abnormalities that presented ten years after chemoradiotherapy in an elderly lung cancer patient.
- Subjects :
- Oncology
medicine.medical_specialty
Down syndrome
Therapy related
Clinical pathology
business.industry
Incidence (epidemiology)
Biochemistry (medical)
Clinical Biochemistry
General Medicine
Disease
medicine.disease
Diagnostic Hematology
Acute megakaryoblastic leukemia
hemic and lymphatic diseases
Internal medicine
medicine
business
Lung cancer
Letter to the Editor
neoplasms
Chemoradiotherapy
Subjects
Details
- ISSN :
- 22343814 and 22343806
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Annals of Laboratory Medicine
- Accession number :
- edsair.doi.dedup.....7802216afd1cc3bba77c910b7816bb99